Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies
Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies
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DOI：
10.1023/a:1015570104121
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发表时间：
2002-04-01
影响因子：
--
通讯作者：
de Blaey, CJ
中科院分区：
文献类型：
--
作者：
Beijer, HJM;de Blaey, CJ
目的：方法：采用文献检索法、Meta分析法，对Medline数据库进行文献检索和Meta分析。结果：从文献中可以看出，相当一部分的住院病例与药物不良反应有关。然而，这些数据并不同质，即较大的研究显示ADR相关住院的百分比较低，而较小的研究显示百分比较高。亚组分析显示，老年人因ADR相关问题住院的几率是年轻人的4倍（16.6% vs. 4.1%）。这些住院治疗中有相当一部分是可以避免的。亚组分析显示，在老年人中，高达88%的ADR相关住院是可以预防的;对于非老年人来说，这一比例仅为24%。相对而言，住院的老年人比年轻人多。结合这些发现，老年人因ADR相关问题住院的人数是非老年人的两倍，而ADR相关住院的可预防性可能使老年人比非老年人多7倍。估计的费用ADR相关的住院治疗在卫生保健系统在荷兰的discussed.Conclusion：许多老年人住院的ADR相关的问题，这些住院治疗的一个重要组成部分可以避免。
Aim: to establish the percentage hospital admission related to adverse drug reactions (ADRs) from the data available in the literature.Method: literature search in the Medline database, meta-analysis.Results: from the literature it is revealed that a considerable part of all hospital admissions are related to adverse drug reactions. However, these data are not homogenous, i.e. larger studies display a lower percentage of ADR related hospital admission, while smaller studies display a higher percentage. Subgroup analysis showed that for elderly people the odds of being hospitalised by ADR related problems is 4 times higher than for younger ones (16.6% vs. 4.1%). A considerable part of these hospitalisations can be prevented. Subgroup analysis revealed that in the elderly up to 88% of the ADR related hospitalisations are preventable; for the non-elderly this is only 24%. Comparatively more elderly people are hospitalised than younger ones. Combining these findings, twice as much elderly people are hospitalised by ADR related problems than non-elderly, while preventability of ADR related hospitalisation might yield 7 times more people in the elderly than in the non-elderly. The estimation of the costs of ADR related hospitalisations in the Health Care system in The Netherlands is discussed.Conclusion: many elderly people are hospitalised by ADR related problems; an important part of these hospitalisations can be avoided.