Spatial navigation impairment in patients with refractory temporal lobe epilepsy: Evidence from a new virtual reality-based task
Spatial navigation impairment in patients with refractory temporal lobe epilepsy: Evidence from a new virtual reality-based task
复制标题
DOI：
10.1016/j.yebeh.2011.07.021
复制
发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
Manuel Cimadevilla, Jose
中科院分区：
文献类型：
--
作者：
Canovas, Rosa;Leon, Irene;Manuel Cimadevilla, Jose
本研究旨在探讨非手术治疗的颞叶癫痫(TLE)患者的空间学习记忆能力。25名位于颞叶的难治性癫痫患者(10名在右半球，15名在左半球)和25名年龄匹配的健康对照组进行了虚拟现实版的开孔板-“盒子房间”的测试。他们接受了10次试验，以在一个房间里找到奖励箱，其中16个是可用的。参与者还完成了全面的神经心理学评估。与对照组相比，患者的表现明显更差。他们走了更远的距离，犯下的错误比控制更多。当癫痫灶的性别或偏侧化被认为是一个自变量时，TLE组内的表现没有发现差异。这些发现表明，两个半球的时间结构的完整性可能对空间学习和记忆至关重要，并支持任务的空间部分。(C)2011 Elsevier Inc.保留所有权利。
This study was aimed at examining spatial learning and memory in nonoperated temporal lobe epilepsy (TLE). Twenty-five patients with a refractory epileptic focus located in the temporal lobe (10 in the right hemisphere and 15 in the left hemisphere) and 25 healthy age-matched controls performed the "Boxes Room," a virtual reality version of the holeboard. They were trained in 10 trials to locate the reward boxes in a room with 16 of them available. Participants also completed a comprehensive neuropsychological evaluation. Patients performed significantly worse relative to the control group. They traveled longer distances and committed more errors than controls. No differences in performance were found within the TLE group when gender or lateralization of the epileptic focus was considered an independent variable. These findings suggest that the integrity of temporal structures in both hemispheres could be critical to spatial learning and memory and support the spatial component of the task. (C) 2011 Elsevier Inc. All rights reserved.