Weight regulation, leptin and growth hormone
Weight regulation, leptin and growth hormone
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DOI：
10.1159/000191340
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发表时间：
1997-01-01
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影响因子：
--
通讯作者：
Considine, RV
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文献类型：
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作者：
Considine, RV
瘦素是脂肪组织特异性ob基因的产物，是一种新发现的参与代谢和体组成调节的激素。瘦素似乎为中枢神经系统提供关于脂肪组织中储存的能量的量的信息。成人、儿童和新生儿的血清瘦素水平与体脂量高度相关。肥胖个体的循环瘦素显著高于正常的瘦个体。尽管瘦素与脂肪量相关，但循环中的瘦素浓度会因能量摄入的极端情况而改变，如禁食和过度喂养。在几种啮齿动物模型中，下丘脑中瘦素或其受体的缺陷导致肥胖的发展;然而，迄今为止，还没有在人类中鉴定出这种有害的缺陷。总之，这些观察结果表明，人类可能对其内源性瘦素水平具有抗性。尽管如此，在啮齿类动物的研究表明，瘦素管理可以导致肥胖症/肥胖症小鼠的体重减轻，并在正常体重控制表明，瘦素可能是有用的，在治疗人类肥胖症，本文将总结目前的认识瘦素及其在调节身体组成的作用。此外，瘦素与其他代谢激素，包括生长激素的相互作用将被讨论。
Leptin, the product of the adipose tissue-specific ob gene, is a newly recognized hormone involved in the regulation of metabolism and body composition. Leptin appears to provide information to the central nervous system on the amount of energy stored in the adipose tissue. Serum leptin levels are highly correlated with body fat mass in adults, children and newborns. Obese individuals have significantly higher circulating leptin than normal, lean subjects. In addition, females have higher serum leptin than males with equivalent fat mass, Although leptin correlates with fat mass, circulating concentrations are altered by extremes in energy intake, such as fasting and overfeeding, Defects in leptin or its receptor in the hypothalamus lead to the development of obesity in several rodent models; however, no such deleterious defects have been identified in humans to date, Taken together, these observations suggest that humans may be resistant to their endogenous leptin levels. Despite this, studies in rodents demonstrating that leptin administration can cause weight loss in both ob/ob mice, and in normal weight controls suggest that leptin may be useful in the treatment of human obesity, This review will summarize the current understanding of leptin and its role in the regulation of body composition. In addition, the interaction of leptin with other metabolic hormones including growth hormone will be discussed.