Upc2p‐associated differential protein expression in Candida albicans
Upc2p‐associated differential protein expression in Candida albicans
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DOI：
10.1002/pmic.200900176
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发表时间：
2009-10
期刊：
影响因子：
3.4
通讯作者：
Christopher F. Hoehamer;Edwin D. Cummings;George M. Hilliard;J. Morschhäuser;P. David Rogers
中科院分区：
文献类型：
--
作者：
Christopher F. Hoehamer;Edwin D. Cummings;George M. Hilliard;J. Morschhäuser;P. David Rogers
The gain‐of‐function mutation G648D in UPC2 causes ERG11 up‐regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2‐DE and PMF to identify proteomic alterations in an ERG11‐overexpressing fluconazole‐resistant C. albicans clinical isolate compared with its fluconazole‐susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild‐type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p‐regulated proteins may contribute to fluconazole resistance in C. albicans.
