Radiation-induced meningiomas: an exhaustive review of the literature.
Radiation-induced meningiomas: an exhaustive review of the literature.
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辐射诱发的脑膜瘤：文献的详尽回顾。
DOI：
10.1016/j.wneu.2016.09.094
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发表时间：
2017
期刊：
影响因子：
2
通讯作者：
Kanayama T
中科院分区：
文献类型：
--
作者：
Yamanaka R;Hayano A;Kanayama T
放射性脑膜瘤（RIM）是一种罕见的晚期风险的颅脑照射。我们进行了详尽的审查，个别患者的数据，以表征RIM.MethodsUsing的PubMed数据库的系统搜索，我们进行了全面的文献综述，以表征和调查RIM。学生测验被用来评估变量之间的差异。Kaplan-Meier分析用于评估生存率。使用log-rank test.ResultsOur分析包括251例RIM的统计学意义进行了评估。原发性病变的平均发病年龄为13.0 ± 13.5岁，该病变的平均辐射剂量为38.8 ± 16.8戈伊。继发性脑膜瘤可分为I级（140），II级（55）和III级（10）肿瘤。多发性脑膜瘤30例（11.9%），复发性脑膜瘤46例（18.3%）。原发灶放疗至脑膜瘤发病的潜伏期为22.9 ± 11.4年。对于III级脑膜瘤患者以及接受全身化疗的高剂量和中剂量放疗组患者，潜伏期较短。侵袭性脑膜瘤和多发性脑膜瘤在高剂量组和中剂量组比低剂量组更常见。所有脑膜瘤患者的5年和10年生存率分别为77.7%和66.1%，respectives.ConclusionsFor颅放疗治疗的患者，继发性脑膜瘤的风险需要一个较长的随访期超过标准的时间框架通常指定为确定原发性肿瘤复发的风险。
ObjectiveRadiation-induced meningioma (RIM) is an uncommon late risk of cranial irradiation. We conducted an exhaustive review of individual patient data to characterize RIM.MethodsUsing a systematic search of the PubMed database, we performed a comprehensive literature review to characterize and investigate RIM. Studentttests were used to evaluate differences between variables. A Kaplan-Meier analysis was used to assess survival. Statistical significance was assessed using a log-rank test.ResultsOur analysis included 251 cases of RIM. The average age at onset for the primary lesion was 13.0 ± 13.5 years, and the average radiation dose delivered to this lesion was 38.8 ± 16.8 Gy. Secondary meningiomas could be divided into grades I (140), II (55), and III (10) tumors. Thirty patients (11.9%) had multiple lesions, and 46 (18.3%) had recurrent meningiomas. The latency period between radiotherapy for primary lesions and the onset of meningiomas was 22.9 ± 11.4 years. The latency period was shorter for patients with grade III meningioma and for those in the high-dose and intermediate-dose radiation groups who received systemic chemotherapy. Aggressive meningiomas and multiple meningiomas were more common in the high-dose and intermediate-dose groups than in the low-dose group. The 5-year and 10-year survival rates for all patients with meningioma were 77.7% and 66.1%, respectively.ConclusionsFor patients treated with cranial radiotherapy, the risk of secondary meningioma warrants a longer follow-up period beyond the standard time frame typically designated for determining the risk of primary tumor relapse.