The relationship between spatial configuration and functional connectivity of brain regions revisited
The relationship between spatial configuration and functional connectivity of brain regions revisited
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DOI：
10.7554/elife.44890
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发表时间：
2019-05-08
期刊：
影响因子：
7.7
通讯作者：
Harrison, Samuel J.
中科院分区：
文献类型：
--
作者：
Bijsterbosch, Janine Diane;Beckmann, Christian F.;Harrison, Samuel J.
之前，我们表明，基于网络的大脑连接建模与大脑区域的形状和确切位置强烈相互作用，使得功能性大脑区域的空间配置中的跨受试者变化被解释为功能性连接的变化（Bijsterbosch等人，2018年）。在这里，我们表明，这些空间效应的连接估计实际上发生的结果，大脑网络之间的空间重叠。这表明，系统的偏见，从组空间伊卡，然后通过二元回归获得的连接估计。我们引入了一个扩展的方法，解决了偏见，实现更准确的连接估计。
Previously we showed that network-based modelling of brain connectivity interacts strongly with the shape and exact location of brain regions, such that cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity (Bijsterbosch et al., 2018). Here we show that these spatial effects on connectivity estimates actually occur as a result of spatial overlap between brain networks. This is shown to systematically bias connectivity estimates obtained from group spatial ICA followed by dual regression. We introduce an extended method that addresses the bias and achieves more accurate connectivity estimates.