Management of dyslipidaemias.
Management of dyslipidaemias.
复制标题
血脂异常的管理。
DOI：
10.1136/hrt.2005.071712
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Knopp,Robert
中科院分区：
文献类型：
--
作者：
Paramsothy,Pathmaja;Knopp,Robert
动脉粥样硬化疾病是欧洲、美国和全世界男性和女性的主要死亡原因。以前被认为是一种“西方”疾病，现在很清楚，不同种族背景的各种人都容易患动脉粥样硬化。肥胖症，特别是腹部肥胖症的流行加剧了对高危个体的适当检测和管理的需要。经济和医疗资源的巨大消耗需要采取预防措施，以减少心脏病的全球负担。最近的Interheart研究是一项在52个国家进行的非常大型的急性心肌梗死病例对照研究，表明冠心病（CHD）的传统危险因素占全球风险的大部分（超过90%），包括血脂异常、吸烟、糖尿病、高血压、腹部肥胖、心理社会因素、水果和蔬菜消费减少、缺乏定期饮酒，缺乏规律的身体活动。全球两个最强有力的风险因素是吸烟和血脂异常。3.冠心病一级和二级预防的最前沿是血脂异常的处理。本文将回顾目前的策略，在管理血脂异常，重点是药物治疗和饮食的预防作用。
Atherosclerotic disease is the leading cause of death among men and women in Europe, the United States, and worldwide. 1 2 Previously considered a ‘‘western’’disease, it is now clear that various peoples of diverse ethnic backgrounds are vulnerable to atherosclerosis. The epidemic of obesity, especially abdominal obesity, escalates the need for appropriate detection and management of high risk individuals. The overwhelming consumption of economic and medical resources necessitates preventive measures in order to decrease the global burden of heart disease. The recent Interheart study, a very large case–control study of acute myocardial infarction in 52 countries, demonstrates that traditional risk factors for coronary heart disease (CHD) account for most of the risk worldwide (over 90%) and include abnormal lipids, smoking, diabetes, hypertension, abdominal obesity, psychosocial factors, diminished consumption of fruits and vegetables, lack of regular alcohol intake, and lack of regular physical activity. The two most potent risk factors worldwide are smoking and dyslipidaemia. 3 The forefront of primary and secondary prevention of CHD is the management of dyslipidaemia. This article will review current strategies in managing dyslipidaemias, focusing on drug treatment and the adjunctive role of diet.