Functional activity related to risk anticipation during performance of the Iowa gambling task
Functional activity related to risk anticipation during performance of the Iowa gambling task
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DOI：
10.1016/j.neuroimage.2004.08.028
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发表时间：
2005-01-01
期刊：
影响因子：
5.7
通讯作者：
Hanakawa, T
中科院分区：
文献类型：
--
作者：
Fukui, H;Murai, T;Hanakawa, T
风险预期是决策过程中一个重要的认知/情感成分。《爱荷华州赌博任务》[Bechara，A.，Damasio，A.R.，Damasio，H.，Anderson，S.W.，1994。对人类前额叶皮质受损后的未来后果不敏感。认知50，7-15]，这是临床研究中最广泛使用的“风险预测任务”，已被证明对涉及腹内侧额前皮质或杏仁核的损害敏感。然而，即使在健康的受试者中，参与这项复杂任务的关键神经回路也尚未完全阐明。使用3-T扫描仪，我们对14名健康受试者进行了与事件相关的功能磁共振成像研究。统计参数图显示，风险预期部分(风险决定减去安全决定)仅激活了额叶内侧回。此外，我们还发现，在高风险决策过程中，任务绩效和大脑活动的大小之间存在显著的个体间相关性。这些结果表明，爱荷华州赌博任务确实招募了在不确定情况下做出决策的关键神经回路，特别是当受试者感知到他们决策的风险时。(C)2004 Elsevier Inc.保留所有权利。
Risk anticipation is an important cognitive/emotional component of decision making. The Iowa Gambling Task [Bechara, A., Damasio, A.R., Damasio, H., Anderson, S.W., 1994. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15], which is the most widely used "risk-anticipation task" in clinical studies, has been demonstrated to be sensitive to lesions involving the ventromedial prefrontal cortex or amygdala. However, the critical neural circuitry involved in this complex task has not yet been fully clarified even in healthy subjects. Using a 3-T scanner, we performed an event-related functional magnetic resonance imaging study in 14 healthy subjects performing the task. The statistical parametric mapping showed that the risk anticipation component (risky decisions minus safe decisions) exclusively activated the medial frontal gyros. Furthermore, we found a significant interindividual correlation between the task performance and the magnitude of brain activity during risky decisions. These results indicate that the Iowa Gambling Task does recruit the neural circuitry that is critical in decision making under uncertainty, particularly when subjects perceive the risk of their decision. (C) 2004 Elsevier Inc. All rights reserved.