Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.
Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.
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DOI：
10.14336/ad.2017.0809
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发表时间：
2018-06
影响因子：
7.4
通讯作者：
Hisatsune T
中科院分区：
文献类型：
--
作者：
Ding Q;Tanigawa K;Kaneko J;Totsuka M;Katakura Y;Imabayashi E;Matsuda H;Hisatsune T
在先前报道的双盲随机对照试验（RCT）中，我们证明了每日补充鹅肌肽（750 mg）和肌肽（250 mg）可改善老年人的脑血流量和记忆功能。在这里，我们对来自同一RCT的MRI数据和测试评分进行了子分析，以确定鹅肌肽/肌肽补充剂是否特别有益于携带APOE e4等位基因的老年人，这是加速大脑衰老和阿尔茨海默病发病的风险基因。我们收集了68名年龄在65岁或以上的参与者的数据，他们接受了12个月的鹅肌肽/肌肽补充剂（ACS）或安慰剂。在试验开始和结束时，使用几种神经心理学测试对受试者进行评估，包括韦氏记忆量表-逻辑记忆（WMS-LM）。我们还收集了两种类型的MRI数据，动脉自旋标记（ASL）和扩散张量成像（DTI）在试验开始和结束。我们发现ACS显著地保留了语言记忆（WMS-LM，F[1，65] = 4.2003，p = 0.0445）和大脑额叶区的血流量（FWE聚类水平，p < 0.001）。基于APOE 4基因型的亚组分析显示，活性组中APOE 4+受试者的前额叶区域的血流（通过ASL分析，p = 0.002）和白质微结构（通过DTI分析，p = 0.003）显著保留，而活性组和安慰剂组中APOE 4-受试者之间无显著差异。ACS对APOE 4携带老年人脑结构和功能的保护作用有待进一步研究证实。
In a previously reported double-blind, randomized controlled trial (RCT), we demonstrated that daily supplementation with anserine (750 mg) and carnosine (250 mg) improves brain blood flow and memory function in elderly people. Here, we conducted a sub-analysis of MRI data and test scores from the same RCT to determine whether anserine/carnosine supplementation specifically benefits elderly people carrying the APOE e4 allele, which is a risk gene for accelerated brain aging and for the onset of Alzheimer’s Disease. We collected data from 68 participants aged 65 years or older who received anserine/carnosine supplementation (ACS) or placebo for 12 months. Subjects were assessed at the start and end of the trial using several neuropsychological tests, including the Wechsler Memory Scale-Logical Memory (WMS-LM). We also collected two types of MRI data, arterial spin labeling (ASL) and diffusion tensor imaging (DTI) at the start and end of the trial. We found that ACS significantly preserved verbal memory (WMS-LM, F[1,65] = 4.2003, p = 0.0445) and blood flow at frontal areas of the brain (FWEcluster level, p < 0.001). Sub-analysis based on the APOE4 genotype showed a significant preservation of blood flow (p = 0.002, by ASL analysis) and white-matter microstructure (p = 0.003, by DTI analysis) at prefrontal areas in APOE4+ subjects in the active group, while there was no significant difference between APOE4- subjects in the active and placebo groups. The effect of ACS in preserving brain structure and function in elderly people carrying APOE4 should be verified by further studies.