Oxygen radicals from arachidonate metabolism in abnormal vascular responses.
Oxygen radicals from arachidonate metabolism in abnormal vascular responses.
复制标题
异常血管反应中花生四烯酸代谢产生的氧自由基。
DOI：
10.1164/ajrccm/136.2.474
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kontos,HA
中科院分区：
文献类型：
--
作者：
Kontos,HA
The involvement of oxygen radicals produced in association with arachidonate metabolism via PGH synthase in cerebral vascular responses is reviewed. PGH synthase generates superoxide in the presence of NADH or NADPH. Lipoxygenase also produces superoxide under similar conditions, but it is a much less important quantitative source for this radical. Radicals from the PGH synthase pathway are producedin vivoduring topical application of arachidonate or bradykinin, a polypeptide that releases endogenous arachidonate from tissues. The vascular changes in response to arachidonate and bradykinin consist of functional, morphological, and biochemical alterations. Oxygen radicals from this pathway appear to play a role in the cerebral vascular changes in acute, severe hypertension and in fluid percussion brain injury.
