Does Hyperthyroidism Increase Risk of Death Due to the Ingestion of Ecstasy?
Does Hyperthyroidism Increase Risk of Death Due to the Ingestion of Ecstasy?
复制标题
甲状腺功能亢进是否会增加因摄入摇头丸而死亡的风险？
DOI：
10.1111/j.1556-4029.2007.00463.x
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发表时间：
2007
影响因子：
1.6
通讯作者：
S. Kish
中科院分区：
文献类型：
--
作者：
T. L. Martin;D. Chiasson;S. Kish
摘要：摇头丸（3,4‐亚甲基二氧甲基苯丙胺，MDMA）是一种具有精神活性的安非他明衍生物，广泛用于娱乐目的。由MDMA引起的急性药物中毒引起的死亡是罕见的，但通常会涉及严重的高热发作。一些摇头丸使用者发生致命药物反应的风险增加的潜在因素尚不清楚。我们报告了一个24岁女性的病例报告，她在使用MDMA后出现致命的高热并伴有多器官并发症，并在尸检中发现弥漫性甲状腺增生（Graves病）。在入院时获得的样本中测量了死前血液MDMA浓度为0.68 mg/L。虽然因果关系无法确定，但由于甲状腺激素是产热的主要调节因子，我们认为甲亢易使受试者发生摇头丸诱导的高热，而先前存在的影响温度状态的缺陷可能是解释一些摇头丸中毒死亡的一个因素。
Abstract: Ecstasy (3,4‐methylenedioxymethamphetamine, MDMA) is a psychoactive amphetamine derivative widely used for recreational purposes. Deaths caused by acute drug intoxication with MDMA are rare but can often involve a severe hyperthermic episode. The factors underlying the increased risk of some ecstasy users to a fatal drug reaction are not known. We present a case report of a 24‐year‐old woman who developed fatal hyperthermia with multi‐organ complications following MDMA use and was found at autopsy to have diffuse thyroid hyperplasia (Graves’ disease). An antemortem blood MDMA concentration of 0.68 mg/L was measured in a sample obtained on admission to hospital. Although a cause and effect cannot be established, as the thyroid hormone is a major regulator of thermogenesis, we suggest that hyperthyroidism predisposed the subject to ecstasy‐induced hyperthermia and that a pre‐existing defect affecting temperature status could be one factor in explaining some ecstasy intoxication deaths.