CORTICAL CORRELATES OF AUDITORY SENSORY GATING: A SIMULTANEOUS NEAR-INFRARED SPECTROSCOPY EVENT-RELATED POTENTIAL STUDY
CORTICAL CORRELATES OF AUDITORY SENSORY GATING: A SIMULTANEOUS NEAR-INFRARED SPECTROSCOPY EVENT-RELATED POTENTIAL STUDY
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DOI：
10.1016/j.neuroscience.2009.01.015
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发表时间：
2009-03-31
期刊：
影响因子：
3.3
通讯作者：
Fallgatter, A. J.
中科院分区：
文献类型：
--
作者：
Ehlis, A. -C.;Ringel, T. M.;Fallgatter, A. J.
感觉门控是指大脑网络抑制对不相关环境刺激做出反应的能力，这是一种保护大脑免受信息溢出影响的机制。重复发生特定声刺激后 P50 振幅（电生理记录中事件相关电位/ERP 的早期组成部分）的降低是定量评估门控机制的一种方法。尽管 P50 抑制已被广泛研究，但迄今为止，关于听觉感觉门控的皮质相关性的神经影像学研究还非常稀疏。近红外光谱 (NIRS) 是一种非常适合听觉范式研究的光学成像技术，因为它几乎不涉及噪声。我们进行了同步 NIRS-ERP 测量，以评估人类听觉感觉门控的皮质相关性。多通道 NIRS 记录表明，在感觉门控增加的情况下（双击试验），前额叶和颞顶叶皮质发生了特定的激活。将血流动力学数据与“门控质量”（门控商 Q）的电生理指标相结合，揭示了左前额叶和颞叶皮层双击期间感觉门控的数量与血流动力学反应强度之间的正相关性。结果与之前的发现一致，并证实了前额叶皮层对初级听觉皮层可能存在的抑制影响。 (C) 2009 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Sensory gating refers to the ability of cerebral networks to inhibit responding to irrelevant environmental stimuli, a mechanism that protects the brain from information overflow. The reduction of the P50 amplitude (an early component of the event-related potential/ERP in electrophysiological recordings) after repeated occurrence of a particular acoustic stimulus is one means to quantitatively assess gating mechanisms. Even though P50 suppression has been extensively investigated, neuroimaging studies on the cortical correlates of auditory sensory gating are so far very sparse. Near-infrared spectroscopy (NIRS) is an optical imaging technique perfectly suitable for the investigation of auditory paradigms, since it involves virtually no noise. We conducted a simultaneous NIRS-ERP measurement to assess cortical correlates of auditory sensory gating in humans. The multi-channel NIRS recording indicated a specific activation of prefrontal and temporo-parietal cortices during conditions of increased sensory gating (dual-click trials). Combining the hemodynamic data with an electrophysiological index of the "gating quality" (gating quotient Q) revealed a positive correlation between the amount of sensory gating and the strength of the hemodynamic response during dual-clicks in the left prefrontal and temporal cortices. The results are in line with previous findings and confirm a possible inhibitory influence of the prefrontal cortex on primary auditory cortices. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.