Two-component systems required for virulence in Pseudomonas aeruginosa.
Two-component systems required for virulence in Pseudomonas aeruginosa.
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DOI：
10.1093/femsle/fnx104
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发表时间：
2017-06-15
影响因子：
2.1
通讯作者：
Porter SL
中科院分区：
文献类型：
--
作者：
Francis VI;Stevenson EC;Porter SL
铜绿假单胞菌是一种多功能的机会致病菌，除了在宿主外的广泛环境条件下繁殖外，还能够感染广泛的宿主。随着这种多功能性的出现，需要严格调控其基因组，以优化其基因表达和行为，以适应当前的条件。双组分系统（TCSs）包括传感器激酶和反应调节剂在这种调节中发挥了重要作用。本小综述讨论了越来越多的TCS与铜绿假单胞菌的毒力有关，特别关注多激酶网络的新兴主题，多激酶网络是由多个传感器激酶组成的网络，它们共同工作，感知和整合多个信号以决定最佳反应。在深度调节过程，如急性和慢性毒力之间的转换（GacS网络），杯菌毛（Roc网络和Rcs/Pvr网络），脂多糖的氨基阿拉伯糖修饰（涉及PhoQP和PmrBA TCS的网络），抽搐运动性和毒力（由Chp化学感受途径和FimS/AlgR TCS形成的网络），和生物膜形成（Wsp化学感受途径）。此外，我们强调这些系统和二级信使信号，如cAMP和c-di-GMP之间的重要接口。控制条件致病菌铜绿假单胞菌毒力的双组分系统。
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad range of hosts, in addition to thriving in a broad range of environmental conditions outside of hosts. With this versatility comes the need to tightly regulate its genome to optimise its gene expression and behaviour to the prevailing conditions. Two-component systems (TCSs) comprising sensor kinases and response regulators play a major role in this regulation. This minireview discusses the growing number of TCSs that have been implicated in the virulence of P. aeruginosa, with a special focus on the emerging theme of multikinase networks, which are networks comprising multiple sensor kinases working together, sensing and integrating multiple signals to decide upon the best response. The networks covered in depth regulate processes such as the switch between acute and chronic virulence (GacS network), the Cup fimbriae (Roc network and Rcs/Pvr network), the aminoarabinose modification of lipopolysaccharide (a network involving the PhoQP and PmrBA TCSs), twitching motility and virulence (a network formed from the Chp chemosensory pathway and the FimS/AlgR TCS), and biofilm formation (Wsp chemosensory pathway). In addition, we highlight the important interfaces between these systems and secondary messenger signals such as cAMP and c-di-GMP. Two-component systems controlling the virulence of the opportunistic pathogen, Pseudomonas aeruginosa.