Short-term, high-dose hydroxychloroquine corneal toxicity.
Short-term, high-dose hydroxychloroquine corneal toxicity.
复制标题
短期、大剂量羟氯喹角膜毒性。
DOI：
10.1016/j.ajoc.2020.100713
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发表时间：
2020
影响因子：
--
通讯作者：
Wozniak,RachelAF
中科院分区：
文献类型：
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作者：
Savage,DanielE;Plotnik,Ronald;Wozniak,RachelAF
PurposeTo描述的角膜调查结果和管理的一个61岁的女性漩涡角膜病变后短期，高剂量羟氯喹用于复发性乳腺癌的临床试验中的设置。ObservationsThe患者被发现有显着的角膜漩涡角膜病变没有视网膜病理3个月内的1200毫克，每日羟氯喹治疗作为辅助药物治疗癌症。停止用药导致1个月内角膜轮状变消退，但视力未恢复至基线。最后，其余的不规则散光和眼表疾病需要巩膜接触透镜，以实现BSCVA的20/25 number.Conclusions和ImportanceHydroxychloroquine诱导的旋涡性角膜病变在很大程度上被认为是剂量和持续时间依赖性的，是不常见的，与大多数标准的治疗算法。然而，随着高剂量羟氯喹在辅助癌症治疗中的使用越来越多，角膜发现可能会变得更加频繁。可能会发生持续性视力损害，因此增加对这种病理学的了解有助于为患者提供咨询和指导治疗建议。
PurposeTo describe the corneal findings and management of a 61-year-old female with vortex keratopathy following short term, high dose hydroxychloroquine used in the setting of a clinical trial for recurrent breast cancer.ObservationsThe patient was found to have significant corneal vortex keratopathy without retinal pathology within 3 months of 1200 mg daily hydroxychloroquine treatment as an adjuvant medication for cancer therapy. Cessation of the medication led to the resolution of the corneal verticillata within 1 month yet the vision did not return to baseline. Ultimately, remaining irregular astigmatism and ocular surface disease required a scleral contact lens to achieve a BSCVA of 20/25 OU.Conclusions and ImportanceHydroxychloroquine-induced vortex keratopathy is largely considered dose and duration dependent and is uncommon with most standard treatment algorithms. However, with increasing use of high-dose hydroxychloroquine in adjunct cancer therapy, corneal findings are likely to become more frequent. Persistent visual impairment may occur, thus increased understanding of this pathology can aid in counseling patients and guiding treatment recommendations.