A framework for advancing our understanding of cancer-associated fibroblasts
A framework for advancing our understanding of cancer-associated fibroblasts
复制标题
推进我们对癌症相关成纤维细胞理解的框架
DOI：
10.1038/s41568-019-0238-1
复制
发表时间：
2020-01-24
影响因子：
78.5
通讯作者：
Werb, Zena
中科院分区：
文献类型：
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作者：
Sahai, Erik;Astsaturov, Igor;Werb, Zena
本共识声明强调了癌症相关成纤维细胞在癌症生物学和进展中的重要性，并呼吁所有癌症研究人员采取行动，规范癌症相关成纤维细胞研究的检测和报告元数据，以促进我们对肿瘤微环境中这一重要细胞类型的理解。癌症相关成纤维细胞（CAFs）是肿瘤微环境的关键组成部分，具有多种功能，包括基质沉积和重塑，与癌细胞的广泛互惠信号相互作用以及与浸润性白细胞的串扰。因此，它们是优化抗癌治疗策略的潜在目标。然而，在正在进行的调节CAFs以获得治疗益处的尝试中存在许多挑战。这包括我们对CAF起源的理解的局限性和CAF功能的异质性，希望保留一些抗肿瘤功能。在CAF生物学领域专家会议的基础上，我们在此共识声明中总结了我们目前的知识，并提出了一个框架，以促进我们对肿瘤微环境中这一关键细胞类型的理解。
This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.