Signaling of cell fate decisions by CLAVATA3 in Arabidopsis shoot meristems
Signaling of cell fate decisions by CLAVATA3 in Arabidopsis shoot meristems
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DOI：
10.1126/science.283.5409.1911
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发表时间：
1999-03-19
期刊：
影响因子：
56.9
通讯作者：
Meyerowitz, EM
中科院分区：
文献类型：
--
作者：
Fletcher, LC;Brand, U;Meyerowitz, EM
在较高的植物中，器官发生是由自我更新的根尖分生组织不断发生的。拟南芥植物在Clavata（Clv1、2和3）基因中具有功能丧失突变的植物具有扩大分生生物并产生额外的花卉器官。遗传分析表明，编码受体激酶的CLV1用CLV3起作用，以控制分生组织细胞增殖和分化之间的平衡。 CLV3编码一个小的预测细胞外蛋白。 clv3在分生组织中非自治的ADS，并在覆盖Clv1结构域的分生组织表面表达。这些蛋白质可以在信号转导途径中充当配体受体对，从而协调相邻的分生物区域之间的生长。
In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1, 2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation. CLV3 encodes a small, predicted extracellular protein. CLV3 ads nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.