Peripheral blood effects in benzene-exposed workers
Peripheral blood effects in benzene-exposed workers
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DOI：
10.1016/j.cbi.2009.12.020
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发表时间：
2010-03-19
影响因子：
5.1
通讯作者：
Irons, Richard D.
中科院分区：
文献类型：
--
作者：
Schnatter, A. Robert;Kerzic, Patrick J.;Irons, Richard D.
苯暴露的血液毒性效应在随后的健康影响的发生中可能是重要的。我们试图通过研究中国上海及周边地区五家工厂的928名工人暴露于广泛的苯浓度，提供有关外周血影响的进一步信息。具体而言，我们试图调查哪些血液指标与苯暴露更密切相关，以及苯的浓度水平导致外周血变化。通过问卷调查获得生活方式习惯和人口统计学信息，并通过评估四个基因（NQO 1，MPO，CYP 2 E1，GSTT 1）的单核苷酸多态性来确定潜在的重要遗传影响。根据个人监测结果估计的每周苯暴露量范围为0.07至872 mg/m3，中位数为7.4 mg/m3。检测12项外周血指标。尽管接触水平较高（>10 ppm），但对贫血和大红细胞症等红细胞指数的影响更大。对苯最敏感的参数似乎是中性粒细胞和平均血小板体积（MPV），苯空气浓度为7.8-8.2 ppm时会产生影响。甲苯暴露是某些外周血效应的潜在混杂因素，指出需要仔细检查职业环境中两种化合物的水平。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
The hematotoxic effects of benzene exposure may be important in the occurrence of subsequent health effects. We sought to provide further information on peripheral blood effects by studying 928 workers in five factories in and around Shanghai, China exposed to a wide range of benzene concentrations. Specifically, we sought to investigate which blood indices are more strongly related to benzene exposure and which concentration levels of benzene result in peripheral blood changes. Lifestyle habits and demographic information was obtained via questionnaire, and potentially important genetic influences were determined by assessing single nucleotide polymorphisms in four genes (NQO1, MPO, CYP2E1, GSTT1). Weekly benzene exposure estimated from individual monitoring results ranged from 0.07 to 872 mg/m(3) with a median value of 7.4 mg/m(3). Twelve peripheral blood indices were examined. Stronger effects on peripheral blood were seen for red cell indices such as anemia and macrocytosis, albeit at higher (>10 ppm) exposure levels. The most sensitive parameters to benzene appeared to be neutrophils and the mean platelet volume (MPV), where effects were seen for benzene air concentrations of 7.8-8.2 ppm. Toluene exposure is a potential confounder for some peripheral blood effects, pointing to the need to scrutinize levels of both compounds in the occupational environment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.