Diversity, ecology and intestinal function of bifidobacteria.
Diversity, ecology and intestinal function of bifidobacteria.
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DOI：
10.1186/1475-2859-13-s1-s4
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发表时间：
2014-08-29
影响因子：
6.4
通讯作者：
O'Connell Motherway M
中科院分区：
文献类型：
--
作者：
Bottacini F;Ventura M;van Sinderen D;O'Connell Motherway M
人类胃肠道是一个微生物群密集的家园，这些微生物群已经进化到对宿主健康做出积极贡献。出生时，基本上无菌的胃肠道（GIT）很快就会被来自母亲和周围环境的微生物定植。在很短的时间内，微生物群就会在（母乳喂养）婴儿的胃肠道内建立起来，其中双歧杆菌是主要成员，尽管它们的数量优势在断奶后消失。双歧杆菌具有众多的健康益处，以及将其纳入功能性食品中所带来的商业相关性，导致人们加强了旨在从分子角度理解该属益生菌属性的研究。在这篇综述中，我们提供了双歧杆菌多样性和生态学的现状。此外，我们还将讨论这一有趣的细菌群在胃肠道中定殖并持续存在的分子机制，从而促进与其宿主的相互作用。
The human gastrointestinal tract represents an environment which is a densely populated home for a microbiota that has evolved to positively contribute to host health. At birth the essentially sterile gastrointestinal tract (GIT) is rapidly colonized by microorganisms that originate from the mother and the surrounding environment. Within a short timeframe a microbiota establishes within the (breastfed) infant's GIT where bifidobacteria are among the dominant members, although their numerical dominance disappears following weaning. The numerous health benefits associated with bifidobacteria, and the consequent commercial relevance resulting from their incorporation into functional foods, has led to intensified research aimed at the molecular understanding of claimed probiotic attributes of this genus. In this review we provide the current status on the diversity and ecology of bifidobacteria. In addition, we will discuss the molecular mechanisms that allow this intriguing group of bacteria to colonize and persist in the GIT, so as to facilitate interaction with its host.