Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst
Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst
复制标题
使用简单的原位生成的镁催化剂，用苯并呋喃-2(3H)-酮催化内消旋氮丙啶的去对称化
DOI：
10.1021/acscatal.5b02177
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发表时间：
2015-12-01
期刊：
影响因子：
12.9
通讯作者：
Wang, Rui
中科院分区：
文献类型：
--
作者：
Li, Dan;Wang, Linqing;Wang, Rui
The first example of catalytic desymmetrization of meso-aziridines with benzofuran-2(3H) -ones is realized by employing a magnesium catalyst utilizing BINOL as a simple and commercially available chiral ligand. Both of the enantiomers of the ring-opening product could be easily accessed by employing (R)- or (S)-BINOL as chiral ligand, respectively. A variety of enantioenriched 3,3disubstituted benzofuran-2(3H)-ones containing multiple linear continuous stereocenters were obtained with moderate to good yields, diastereo- and enantioselectivities.
