EFFECT OF SALMON-CALCITONIN ON THE INFILTRATION OF LYMPHOCYTES-T IN A SYNOVIUM-LIKE MEMBRANE OF A RAT INFLAMMATORY MODEL
EFFECT OF SALMON-CALCITONIN ON THE INFILTRATION OF LYMPHOCYTES-T IN A SYNOVIUM-LIKE MEMBRANE OF A RAT INFLAMMATORY MODEL
复制标题
DOI：
10.1007/bf01966462
复制
发表时间：
1990-03-01
期刊：
影响因子：
--
通讯作者：
SCHAFFNER, W
中科院分区：
文献类型：
--
作者：
GRIEDER, A;FELDER, M;SCHAFFNER, W
本文观察了鲑鱼降钙素（SCT）对Wistar大鼠背部气囊内衬膜上T淋巴细胞聚集的影响。从空气空化后的第0天到第7天，通过每天将2.5-20 μ g/kg直接注射到空气腔中来给予SCT。与生理盐水对照组相比，SCT治疗引起的T淋巴细胞，T辅助细胞和T非辅助细胞亚群在滑膜样气囊衬里的百分比明显减少，所揭示的FITC标记的单克隆抗体和定量的流式细胞光度测量。这种效应可能是由于SCT引起的局部血管通透性降低。
The effect of salmon calcitonin (SCT) on the number of T lymphocytes accumulating in air pouch lining membranes produced on the back of Wistar rats was studied. SCT was given from day 0 through day seven following the air cavitation by daily injections of 2.5-20 .mu.g/kg directly into the air cavity. Compared with saline controls, treatment with SCT caused a clear reduction in percentage of T lymphocytes, T helper cells and T non-helper subset in the synovial-like air pouch lining as revealed by FITC-labeled monoclonal antibodies and quantified by flow cytophotometric measurements. This effect may be due to a reduction in local vascular permeability caused by SCT.