Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.
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DOI：
10.3978/j.issn.2218-676x.2013.08.09
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发表时间：
2013-08-01
影响因子：
0.9
通讯作者：
Tsourkas A
中科院分区：
文献类型：
--
作者：
Dorsey JF;Sun L;Joh DY;Witztum A;Kao GD;Alonso-Basanta M;Avery S;Hahn SM;Al Zaki A;Tsourkas A
金纳米颗粒（GNP）在治疗和诊断癌症应用中的潜力越来越受到认可。这些生物相容性颗粒可以容易地合成，调整到不同的尺寸，并通过与各种生物有用的材料缀合而官能化。然后可以通过在渗漏的肿瘤血管和组织中被动积累或通过直接靶向肿瘤特异性生物标志物来实现向肿瘤组织的有效和特异性递送。肿瘤定位的GNP可以用作增强放射治疗功效的佐剂，也可以用作各种成像方式的造影剂。本文就GNP作为放射增敏剂和造影剂的最新研究进展和应用前景作一综述。由于其多功能性和生物相容性，金纳米颗粒可能代表癌症治疗中放射应用的新型治疗诊断佐剂。
The potential of gold nanoparticles (GNPs) in therapeutic and diagnostic cancer applications is becoming increasingly recognized. These biologically compatible particles can be easily synthesized, tuned to different sizes, and functionalized by conjugation to various biologically useful materials. Efficient and specific delivery to tumor tissue can then be accomplished either by passive accumulation in leaky tumor vessels and tissue, or by directly targeting tumor-specific biomarkers. Tumor-localized GNPs can serve as both adjuvants for enhancing the efficacy of radiation therapy and also as contrast agents for various imaging modalities. In this review, we will discuss recent advancements and future potential in the application of GNP as both a radiosensitizer and an imaging contrast agent. Due to their versatility and biocompatibility, gold nanoparticles may represent a novel theranostic adjuvant for radiation applications in cancer management.