Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population
Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population
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DOI：
10.1093/ajcn/84.3.646
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发表时间：
2006-09-01
影响因子：
7.1
通讯作者：
Comuzzie, Anthony G.
中科院分区：
文献类型：
--
作者：
Butte, Nancy F.;Cai, Guowen;Comuzzie, Anthony G.
背景：遗传和环境因素对儿童肥胖的影响尚不清楚。目的：Viva la Familia研究旨在绘制西班牙裔儿童肥胖及其合并症的遗传图谱。本报告的目的是描述研究设计，并总结遗传和环境对西班牙裔儿童肥胖表型变异和代谢性疾病危险因素的影响。设计：Viva la Familia队列由来自319个家庭的1030名儿童组成，这些儿童是根据年龄在4岁至19岁之间的超重先证选择的。对超重儿童及其兄弟姐妹进行深入表型分析，包括通过双能x线吸收仪测量人体测量和身体组成特征，通过24小时回忆评估饮食，通过加速度计评估身体活动，以及通过标准生化方法评估代谢性疾病的危险因素。采用单变量定量遗传分析方法，利用计算机程序SOLAR将表型变异划分为加性遗传因子和环境因子。结果：性别、年龄和环境协变量解释了1-91%的表型变异。人体测量指数的遗传率为0.24 ~ 0.75。体组成性状的遗传力系数为0.18 ~ 0.35。饮食和体力活动的遗传力为0.32 ~ 0.69。代谢性疾病的危险因素可遗传，系数在0.25 ~ 0.73之间。肥胖特征与代谢性疾病危险因素之间的显著遗传相关性证实了性状之间的多效性。结论：“家庭万岁”研究为西班牙裔儿童肥胖及其合并症的高患病率提供了强有力的遗传因素的证据。
Background: Genetic and environmental contributions to childhood obesity are poorly delineated.Objective: The Viva la Familia Study was designed to genetically map childhood obesity and its comorbidities in the Hispanic population. The objectives of this report were to describe the study design and to summarize genetic and environmental contributions to the phenotypic variation in obesity and risk factors for metabolic diseases in Hispanic children.Design: The Viva la Familia cohort consisted of 1030 children from 319 families selected based on an overweight proband between the ages of 4 and 19 y. In-depth phenotyping to characterize the overweight children and their siblings included anthropometric and body-composition traits by dual-energy X-ray absorptiometry and assessments of diet by 24-h recalls, physical activity by accelerometry, and risk factors for metabolic diseases by standard biochemical methods. Univariate quantitative genetic analysis was used to partition phenotypic variance into additive genetic and environmental components by using the computer program SOLAR.Results: Sex, age, and environmental covariates explained 1-91% of the phenotypic variance. Heritabilities of anthropornetric indexes ranged from 0.24 to 0.75. Heritability coefficients for the body-composition traits ranged from 0.18 to 0.35. Diet and physical activity presented heritabilities of 0.32 to 0.69. Risk factors for metabolic diseases were heritable with coefficients ranging from 0.25 to 0.73. Significant genetic correlations between obesity traits and risk factors for metabolic diseases substantiated pleiotropy between traits.Conclusion: The Viva la Familia Study provides evidence of a strong genetic contribution to the high prevalence of obesity and its comorbidities in Hispanic children.