Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia
Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia
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DOI：
10.1179/1607845414y.0000000186
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发表时间：
2015-05-01
期刊：
影响因子：
1.9
通讯作者：
Qiu, Hongxia
中科院分区：
文献类型：
--
作者：
Hu, Yixin;Lv, Xin;Qiu, Hongxia
目的：方法：采用流式细胞术对134例急性髓系白血病（101例）和急性淋巴细胞白血病（33例）患者进行系统分析。B7-H3表达率在个别病例中从0%到74.8%不等。B7-H3表达与传统的预后因素如年龄、性别、白色细胞计数的相关性尚不明确。结论：由于B7-H3的表达在预测疾病进展和较短的生存期方面具有统计学相关性，我们的研究结果表明，B7-H3在急性白血病中的表达预示着不利的结果。
Objectives: This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia.Methods: We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry.Results: The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes.Conclusions: Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.