Comparison of bare metal and statin-coated coils on rates of intra-aneurysmal tissue organization in a rat model of aneurysm.
Comparison of bare metal and statin-coated coils on rates of intra-aneurysmal tissue organization in a rat model of aneurysm.
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比较裸金属线圈和他汀类药物涂层弹簧圈对大鼠动脉瘤模型中动脉瘤内组织组织率的影响。
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发表时间：
2013
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影响因子：
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通讯作者：
H. Iwata
中科院分区：
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作者：
T. Kodama;H. Iwata
使用可拆卸弹簧圈血管内治疗颅内动脉瘤已被广泛接受。动脉瘤口处的线圈压缩、再通和罕见内皮化的问题尚未解决。我们研究了在大鼠动脉瘤模型中，在不添加任何额外基质的情况下，将辛伐他汀涂层应用于线圈以加速腔内血栓形成的功效。将 12 个涂有辛伐他汀的金属线圈和 12 个裸线圈插入结扎的大鼠颈外动脉 (ECA) 囊中。植入线圈后 2 或 4 周取出 ECA 囊，并通过组织学和免疫组织化学测定进行检查。辛伐他汀组 ECA 囊的组织面积（2 周时为 73.6 ± 19.4%；4 周时为 83.4 ± 11.1%）显着较高，2 周时，p = 0.003； p = 0.0004，4 周，与裸金属组在第 2 周和第 4 周相比（20.5 ± 10.7%，2 周，p < 0.003；37.4 ± 20.6%，4 周，p < 0.0004）。在涂有辛伐他汀的线圈周围形成的组织组织的特征是αSMA和胶原结缔基质呈阳性的细胞聚集。组织还伴随着 ECA 囊口处内皮细胞的显着形成。我们建议用辛伐他汀涂覆线圈可有效加速动脉瘤内的组织和线圈上的内皮化。
Endovascular treatment of intracranial aneurysms with detachable coils has been accepted widely. Problems of coil compaction, recanalization and rare endothelialization at the aneurysm orifice are not yet solved. We investigated the efficacy of a simvastatin coating applied without any additional matrix to coils to accelerate thrombus organization in the cavity in a rat model of aneurysm. Twelve metal coils coated with simvastatin and 12 bare coils were inserted into the ligated external carotid arterial (ECA) sacs of rats. The ECA sacs were removed 2 or 4 weeks after the coils were implanted and examined by histology and immunohistochemical assay. The organized areas in the ECA sacs in the simvastatin group (73.6 ± 19.4%, 2 wk; 83.4 ± 11.1%, 4 wk) was significantly higher p = 0.003, 2 wk; p = 0.0004, 4 wk than the bare metal group at 2 and 4 weeks (20.5 ± 10.7%, 2 wk, p < 0.003; 37.4 ± 20.6%, 4 wk, p < 0.0004). Organized tissues that formed around the coils coated with simvastatin were characterized by an accumulation of cells positive for αSMA and collagen connective matrix. Tissues also were accompanied by marked formation of endothelium at the orifice of the ECA sac. We suggest that coating coils with simvastatin effectively accelerated organization within the aneurysms and endothelialization over the coil.