Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway
Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway
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DOI：
10.1016/s1097-2765(01)00263-5
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发表时间：
2001-06-01
期刊：
影响因子：
16
通讯作者：
Klionsky, DJ
中科院分区：
文献类型：
--
作者：
Scott, SV;Guan, J;Klionsky, DJ
Cvt19是利用细胞质-液泡靶向（Cvt）途径运输驻留液泡水解酶所特别需要的。自噬（Apg）和自噬（pexophagy）是与Cvt途径使用大部分相同蛋白质成分的过程，不需要Cvt19。Cvt19GFP定位于液泡表面或液泡表面附近的点状结构。Cvt19是一种外周膜蛋白，它与Cvt货运蛋白氨基肽酶I （prAPI）的前体结合，并随prAPI一起进入液泡。这些结果表明，Cvt19是prAPI的受体蛋白，允许该蛋白通过Cvt和Apg途径选择性运输。
Cvt19 is specifically required for the transport of resident vacuolar hydrolases that utilize the cytoplasmto-vacuole targeting (Cvt) pathway. Autophagy (Apg) and pexophagy, processes that use the majority of the same protein components as the Cvt pathway, do not require Cvt19. Cvt19GFP is localized to punctate structures on or near the vacuole surface. Cvt19 is a peripheral membrane protein that binds to the precursor form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole with prAPI. These results suggest that Cvt19 is a receptor protein for prAPI that allows for the selective transport of this protein by both the Cvt and Apg pathways.