Low-cost, transparent, and flexible single-walled carbon nanotube nanocomposite based ion-sensitive field-effect transistors for pH/glucose sensing
Low-cost, transparent, and flexible single-walled carbon nanotube nanocomposite based ion-sensitive field-effect transistors for pH/glucose sensing
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DOI：
10.1016/j.bios.2010.03.003
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发表时间：
2010-06-15
影响因子：
12.6
通讯作者：
Cui, Tianhong
中科院分区：
文献类型：
--
作者：
Lee, Dongjin;Cui, Tianhong
低成本、透明且柔性的离子敏感场效应晶体管（ISFET）被用作pH和葡萄糖传感器。单壁碳纳米管（SWCNT）和聚二烯丙基二甲基氯化铵（PDDA）通过层层自组装（LbL）沉积在聚对苯二甲酸乙二醇酯基底上图案化的两个金属电极之间。pH型ISFET的特性基于以下事实：SWCNT纳米复合材料的电子电导由SWCNT上羧基的分子质子化/去质子化以及外部的Ag/AgCl参比栅极电压决定。借助葡萄糖氧化酶（GOx），通过SWCNT附近局部pH的变化来检测葡萄糖。该葡萄糖传感器在2 - 10 mM的线性范围内显示出18 - 45 μA/mM的灵敏度。表观米氏常数为14.2 mM，表明层层组装的GOx对葡萄糖具有高亲和力。纳米材料和酶在透明且柔性基底上的层层自组装表明其适用于体内应用的各种化学和生物传感器。由爱思唯尔公司出版。
Low-cost, transparent, and flexible ion-sensitive field-effect transistors (ISFETs) are presented as pH and glucose sensors. Single-walled carbon nanotubes (SWCNTs) and poly(diallyldimethyammonium chloride, PDDA) are deposited by layer-by-layer (LbL) self-assembly between two metallic electrodes patterned on a polyethylene terephthalate substrate. The pH ISFETs are characterized based on the fact that the electronic conductance of SWCNTs nanocomposite is determined by molecular Koronation/deprotonation of carboxylic groups on SWCNTs and by the external Ag/AgCl reference gate voltage. Glucose is detected by the local pH change in the vicinity of SWCNTs with the aid of glucose oxidase (GOx) enzyme. The glucose sensor shows a sensitivity of 18-45 mu A/mM on a linear range of 2-10 mM. The apparent Michaelis-Menten constant is 14.2 mM, indicating a high affinity of LbL assembled GOx to glucose. The LbL self-assembly of nanomaterials and enzymes on the transparent and flexible substrate suggests various chemical and biological sensors suitable for in vivo application. Published by Elsevier B.V.