Adenosquamous carcinoma of the upper aerodigestive tract: A clinicopathologic study of 12 cases and review of the literature
Adenosquamous carcinoma of the upper aerodigestive tract: A clinicopathologic study of 12 cases and review of the literature
复制标题
DOI：
10.1053/ajot.2002.123462
复制
发表时间：
2002-05-01
影响因子：
2.5
通讯作者：
Barnes, L
中科院分区：
文献类型：
--
作者：
Keelawat, S;Liu, CZ;Barnes, L
目的：腺鳞癌是一种少见的，有争议的肿瘤。为了进一步了解其自然史，我们对12例新病例的临床和病理特征进行了回顾性分析，并与英文文献中的描述进行了比较。12例上呼吸消化道腺鳞癌，在匹兹堡大学长老会医院的解剖病理学档案中鉴定了up和可用的显微镜载玻片和石蜡组织块结果：男8例，女4例，年龄34 ~ 81岁，平均62.8岁。喉（5例）和口底（4例）是最常见的起源部位。9例患者颈部淋巴结癌阳性（8例诊断），7例局部复发，2例远处转移。10例随访患者中有4例（40%）死于疾病。结合我们的案例和文献中的案例58例患者中，64.7%的患者伴有颈淋巴结转移，46.7%的患者局部复发，23.1%的患者出现远处转移，42.9%的患者在平均24.7个月的随访期内死亡。腺鳞癌是一种侵袭性肿瘤，具有早期淋巴结转移的倾向，经常局部复发，偶尔远处转移，通常在2-3年内死于疾病。颈淋巴结清扫术是治疗的首选。版权所有2002，爱思唯尔科学（美国）。All rights reserved.
Purpose: Adenosquamous carcinoma is an uncommon, controversial neoplasm. To further comprehend its natural history, the clinical and pathological features of 12 new cases were reviewed and analyzed collectively with those described in the English literature.Materials and Methods: Twelve cases of adenosquamous carcinoma of the upper aerodigestive tract with adequate follow-up and available microscopic slides and paraffin tissue blocks were identified in the anatomic pathology files of Presbyterian Hospital of the University of Pittsburgh Medical Center over the period 1983-2001.Results: The 8 men and 4 women ranged in age from 34 to 81 years (mean, 62.8 years). The larynx (5 cases) and the floor of the mouth (4 cases) were the most common sites of origin. Nine patients had cervical lymph nodes positive for carcinoma (8 at diagnosis), 7 experienced local recurrences, and 2 developed distant metastases. Four of 10 (40%) patients with follow-up died of disease. Combining our cases with those in the literature (total of 58 cases) revealed similar findings: 64.7% were associated with positive cervical lymph nodes, 46.7% experienced local recurrences, 23.1% developed distant metastases, and 42.9% died of their disease at a mean follow-up period of 24.7 months.Conclusions: Adenosquamous carcinoma is an aggressive neoplasm with a tendency for early lymph node metastasis, frequent local recurrence, occasional distant metastasis, and death from disease, usually within 2-3 years. Surgery with neck dissection is the treatment of choice. Copyright 2002, Elsevier Science (USA). All rights reserved.