Cholecystokinin elicits the complete behavioral sequence of satiety in rats.
Cholecystokinin elicits the complete behavioral sequence of satiety in rats.
复制标题
胆囊收缩素引起大鼠饱腹感的完整行为序列。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
G. P. Smith
中科院分区：
文献类型：
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作者：
J. Antin;J. Gibbs;J. Holt;R. Young;G. P. Smith
在禁食17小时后给予流食，在60分钟的测试期间观察完整大鼠和慢性胃瘘大鼠的行为并进行评分。完好的大鼠和瘘管闭合的大鼠在每顿饭结束时都表现出一种特定的行为顺序：它们停止进食，进行短暂的梳理和探索，然后休息或睡觉。因此，固定的行为序列是大鼠饱腹感的特征。虽然饱腹感的行为序列是固定的，但停止喂食并不是其余序列出现的充分条件：奎宁掺假的液体饮食停止了假喂养，但并没有引发完整的序列。然而，在假性喂养期间，腹腔注射肠道激素胆囊收缩素可以诱导完整的饱腹感序列。观察到胆囊收缩素不仅停止进食，而且引发完整的饱腹感序列，这支持了我们的假设，即内源性胆囊收缩素是大鼠的饱腹感信号。
The behavior of intact rats and rats with chronic gastric fistulas was observed and scored during a 60-min test period when they were offered liquid diet after 17 hr of food deprivation. Intact rats and rats with closed fistulas displayed a specific behavioral sequence at the end of each meal: They stopped eating, engaged in grooming and exploration for a short time, and then rested or slept. Thus, a fixed behavioral sequence characterizes satiety in the rat. Although the behavioral sequence of satiety was fixed, the cessation of feeding was not a sufficient condition for the appearance of the rest of the sequence: Quinine adulteration of the liquid diet stopped sham feeding but did not elicit the complete sequence. Intraperitoneal injection of the intestinal hormone cholecystokinin during sham feeding, however, elicited the complete sequence of satiety. The observation that cholecystokinin not only stops feeding but elicits the complete sequence of satiety supports our hypothesis that endogenous cholecystokinin is a satiety signal for the rat.