Effect of tube current on computed tomography radiomic features.
Effect of tube current on computed tomography radiomic features.
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DOI：
10.1038/s41598-018-20713-6
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发表时间：
2018-02-05
影响因子：
4.6
通讯作者：
Court L
中科院分区：
文献类型：
--
作者：
Mackin D;Ger R;Dodge C;Fave X;Chi PC;Zhang L;Yang J;Bache S;Dodge C;Jones AK;Court L
计算机断层扫描中使用的x射线管电流的可变性可能影响从图像中提取的定量特征。为了研究这些影响，我们扫描了Credence Cartridge Radiomics幻影12次，将电子管电流从25到300 mA∙s变化，同时保持其他采集参数不变。对于每次扫描，我们从强度直方图（n = 10）、灰度运行长度矩阵（n = 11）、灰度共生矩阵（n = 22）和邻域灰度差矩阵（n = 5）中提取48个放射学特征。为了测量管电流效应的大小，我们通过从非小细胞肺癌肿瘤图像中提取的相应特征的变异系数对特征进行缩放。管电流的变化对从同质材料（丙烯酸、梧桐木）中提取的特征比从具有更多组织状纹理的材料（软木、橡胶颗粒）中提取的特征影响更大。从丙烯酸中提取的48个特征中有38个受到电流减少的影响，而从橡胶颗粒中提取的48个特征中只有2个受到电流减少的影响。这些结果表明，可变的x射线管电流不太可能对从纹理物体（如肿瘤）的计算机断层扫描图像中提取的放射学特征产生大的影响。
Variability in the x-ray tube current used in computed tomography may affect quantitative features extracted from the images. To investigate these effects, we scanned the Credence Cartridge Radiomics phantom 12 times, varying the tube current from 25 to 300 mA∙s while keeping the other acquisition parameters constant. For each of the scans, we extracted 48 radiomic features from the categories of intensity histogram (n = 10), gray-level run length matrix (n = 11), gray-level co-occurrence matrix (n = 22), and neighborhood gray tone difference matrix (n = 5). To gauge the size of the tube current effects, we scaled the features by the coefficient of variation of the corresponding features extracted from images of non-small cell lung cancer tumors. Variations in the tube current had more effect on features extracted from homogeneous materials (acrylic, sycamore wood) than from materials with more tissue-like textures (cork, rubber particles). Thirty-eight of the 48 features extracted from acrylic were affected by current reductions compared with only 2 of the 48 features extracted from rubber particles. These results indicate that variable x-ray tube current is unlikely to have a large effect on radiomic features extracted from computed tomography images of textured objects such as tumors.
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