INFIDELITY IN THE STRUCTURE OF ECTOPIC TRANSCRIPTS - A NOVEL EXON IN LYMPHOCYTE DYSTROPHIN TRANSCRIPTS
INFIDELITY IN THE STRUCTURE OF ECTOPIC TRANSCRIPTS - A NOVEL EXON IN LYMPHOCYTE DYSTROPHIN TRANSCRIPTS
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DOI：
10.1002/humu.1380020409
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发表时间：
1993-01-01
期刊：
影响因子：
3.9
通讯作者：
BOBROW, M
中科院分区：
文献类型：
--
作者：
ROBERTS, RG;BENTLEY, DR;BOBROW, M
异位（或“非法”）转录本最近已成为流行的一种手段，以促进转录本的研究，通常认为有一个模式的表达仅限于一个或几个组织。人们通常认为，异位转录物的结构忠实地代表了其组织特异性对应物的结构。在这里，我们描述了一个新的外显子在50%的异位肌营养不良蛋白转录人外周血淋巴细胞的列入。该新序列类似于癌胚抗原基因家族成员的3'非翻译区中的保守区，并且位于人肌营养不良蛋白基因的第一内含子内。这构成了一个显着偏离预期的体内剪接行为在异位转录，并表明可能有例外的假设，异位转录处理以类似的方式，他们的组织特异性对应物。 (C)1993 Wiley-Liss，Inc.
Ectopic (or ''illegitimate'') transcripts have recently become popular as a means of facilitating the study of transcripts normally considered to have a pattern of expression restricted to one or a few tissues. It has been generally assumed that the structure of an ectopic transcript faithfully represents that of its tissue-specific counterpart. We describe here the inclusion of a novel exon in 50% of ectopic dystrophin transcripts from human peripheral blood lymphocytes. The novel sequence resembles a conserved region in the 3' untranslated region of members of the carcinoembryonic antigen gene family and lies within the first intron of the human dystrophin gene. This constitutes a significant departure from the expected in vivo splicing behaviour in an ectopic transcript and suggests that there may be exceptions to the assumption that ectopic transcripts are processed in a similar way to their tissue-specific counterparts. (C) 1993 Wiley-Liss, Inc.