Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
复制标题
DOI：
10.1016/j.atherosclerosis.2008.06.007
复制
发表时间：
2009-03-01
期刊：
影响因子：
5.3
通讯作者：
Anand, Sonia S.
中科院分区：
文献类型：
--
作者：
Burman, Debika;Mente, Andrew;Anand, Sonia S.
背景：心血管危险因素和动脉粥样硬化的患病率在不同种族群体之间存在差异。我们研究了载脂蛋白E（ApoE）的多态性，它与血脂性状和动脉粥样硬化，其种族差异对血脂traits.Methods的影响：在一项随机抽样的横断面研究985南亚。结果：E2、E3和E4等位基因频率分别为5.7%、84.0%和10.2%，不同种族间差异有统计学意义（P <0.01）。ApoE与除甘油三酯外的每种血脂性状之间存在强烈的逐步相关性。E4基因型与较高的低密度脂蛋白胆固醇（趋势p < 0.001）、ApoB（p < 0.001）、ApoB/ApoA比值（U < 0.001）和脂蛋白（a）（p < 0.001）相关。降低ApoA（p < 0.001）和高密度脂蛋白胆固醇（HDL-C）（p=0.005）。在所有族裔群体中观察到类似的影响模式。种族可解释ApoA、ApoB/ApoA比值和HDL-C的适度变异（4.2-5.0%），而ApoE亚型仅解释小部分变异（0.3-1.4%）。饮食和生活方式因素导致包括HDL-C在内的几个性状的适度变化（分别为5.6%和5.0%）。颈动脉粥样硬化是较低的E2亚型与E2对血脂level.Conclusions的影响保持个体之间：ApoE亚型与血浆脂蛋白在所有种族群体，但解释只有一小部分的种族间的变化，大多数血浆脂蛋白。其他遗传变异和/或健康行为可能导致血脂性状的种族差异。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Background: The prevalence of cardiovascular risk factors and atherosclerosis vary between ethnic groups. We examined the apolipoprotein E (ApoE) polymorphism, its association with lipid traits and atherosclerosis, and its influence on ethnic variations on lipid traits.Methods: In a randomly sampled cross-sectional study of 985 South Asian. Chinese, and European Canadians, three common isoforms of ApoE (E2, E3 and E4), plasma lipid concentrations and atherosclerosis of the carotid artery were measured.Results: The E2, E3 and E4 allele frequencies were 5.7%, 84.0%, and 10.2%, respectively, and differed significantly between ethnic groups. There was a strong, stepwise association between ApoE and each plasma lipid trait, except triglycerides. The E4 genotype was associated with higher low-density lipoprotein cholesterol (p for trend < 0.001), ApoB (p < 0.001), ApoB/ApoA ratio U) < 0.001) and lipoprotein (a) (p < 0.001). and lower ApoA (p < 0.001) and high-density lipoprotein cholesterol (HDL-C) (p=0.005). A similar pattern of effects was observed across all ethnic groups. Ethnicity accounted for modest variation in ApoA, ApoB/ApoA ratio and HDL-C (4.2-5.0%), whereas ApoE isoforms explained only a small proportion of variability (0.3-1.4%). Dietary and lifestyle factors accounted for modest variation in several traits including HDL-C (5.6% and 5.0%, respectively). Carotid atherosclerosis was lower among individuals with E2 isoform in keeping with the effect of E2 on lipid levels.Conclusions: The ApoE isoform is associated with plasma lipoproteins in all ethnic groups, yet explains only a small proportion of the inter-ethnic variation for most plasma lipoproteins. Additional genetic variants and/or health behaviors likely contribute to ethnic variations in plasma lipid traits. (C) 2008 Elsevier Ireland Ltd. All rights reserved.