Effects of spinal and peripheral nerve lesions on the intersegmental synchronization of the spontaneous activity of dorsal horn neurons in the cat lumbosacral spinal cord
Effects of spinal and peripheral nerve lesions on the intersegmental synchronization of the spontaneous activity of dorsal horn neurons in the cat lumbosacral spinal cord
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DOI：
10.1016/j.neulet.2003.12.068
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发表时间：
2004-05-06
影响因子：
2.5
通讯作者：
Rudomin, P
中科院分区：
文献类型：
--
作者：
García, CA;Chávez, D;Rudomin, P
在麻醉和瘫痪的猫，自发性负索背电位（nCDPs）同步出现在U到S I段，同侧和对侧。完整腓肠神经和腓浅神经的急性部分增加了自发性nCDP的变异性，而不影响其节段间耦合。另一方面，在左侧（同侧）背外侧脊髓象限的介入性病变后，L5-L 6节段中记录的自发nCDP之间的同步性强烈降低，并且在同一水平对侧背外侧象限的额外病变几乎完全消除。我们的观察结果支持存在一个系统的自发活动的背角神经元是双边分布沿着腰骶段和影响，在一个同步和有组织的方式，脉冲传输沿着许多反射通路，包括那些介导突触前抑制。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
In the anesthetized and paralyzed cat, spontaneous negative cord dorsum potentials (nCDPs) appeared synchronously in the U to S I segments, both ipsi- and contralaterally. The acute section of both the intact sural and the superficial peroneal nerve increased the variability of the spontaneous nCDPs without affecting their intersegmental coupling. On the other hand, the synchronization between the spontaneous nCDPs recorded in segments L5-L6 was strongly reduced following an interposed lesion of the left (ipsilateral) dorsolateral spinal quadrant and it was almost completely abolished by an additional lesion of the contralateral dorsolateral quadrant at the same level. Our observations support the existence of a system of spontaneously active dorsal horn neurons that is bilaterally distributed along the lumbosacral segments and affects, in a synchronized and organized manner, impulse transmission along many reflex pathways, including those mediating presynaptic inhibition. (C) 2003 Elsevier Ireland Ltd. All rights reserved.