Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection
Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection
复制标题
刺突蛋白 mFc 融合受体结合域 (RBD) 作为抗 SARS-CoV-2 感染亚单位疫苗的构建和免疫原性研究。
DOI：
10.1039/d0cc03263h
复制
发表时间：
2020-08-07
影响因子：
4.9
通讯作者：
Liao, Guochao
中科院分区：
文献类型：
--
作者：
Qi, Xiaoxiao;Ke, Bixia;Liao, Guochao
Herein, we report that a recombinant fusion protein, containing a 457 amino acid SARS-CoV-2 receptor binding domain (RBD, residues 319-541) and a mouse IgG1 Fc domain, could induce highly potent neutralizing antibodies and stimulate humoral and cellular immunity in mice. The antibodies also effectively suppressed SARS-CoV-2 RBD binding to soluble ACE2, indicating that RBD-mFc may be further developed as a safe and effective SARS-CoV-2 vaccine.
