DISRUPTION IN THE AU MOTIF OF THE MOUSE TNF-ALPHA 3' UTR CORRELATES WITH REDUCED TNF PRODUCTION BY MACROPHAGES IN-VITRO
DISRUPTION IN THE AU MOTIF OF THE MOUSE TNF-ALPHA 3' UTR CORRELATES WITH REDUCED TNF PRODUCTION BY MACROPHAGES IN-VITRO
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DOI：
10.1093/nar/21.11.2761
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发表时间：
1993-06-11
影响因子：
14.9
通讯作者：
TASHMAN, NB
中科院分区：
文献类型：
--
作者：
JACOB, CO;TASHMAN, NB
Many cytokine mRNAs exhibit a conserved, AU-rich motif in the 3'-untranslated region (UTR) of the molecule. Such sequence elements have been implicated in the regulation of mRNA turnover and as potential translational regulators. We report on the identification of a 3 base pair insertion which disrupts the AU motif of the TNF-alpha gene in the NZW, B10.KPA44, SM/J and Mus spretus mice and an insertion of an 8 base pair sequence into the 3' AU motif of the IL-10 gene in the Mus Spretus mouse. The mutation in the AU motif of the TNF-alpha gene correlates with reduced production of this cytokine by peritoneal macrophages from these mouse strains.
