Repeatability and Reproducibility of a Clinically Based QUS Phantom Study and Methodologies.
Repeatability and Reproducibility of a Clinically Based QUS Phantom Study and Methodologies.
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基于临床的QUS幻影研究和方法论的可重复性和可重复性。
DOI：
10.1109/tuffc.2016.2588979
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
O'Brien WD
中科院分区：
文献类型：
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作者：
Han A;Andre MP;Erdman JW;Loomba R;Sirlin CB;O'Brien WD
本研究的目的是评估定量超声（QUS）估计的重复性和再现性（R&R），特别是衰减系数（AC）和后向散射系数（BSC），使用相同的西门子3000临床超声扫描仪。此外，本工作的目的是详细的测量和分析方法。重复性是在相同条件下（相同超声仪和相同换能器）用相同方法获得的测量结果之间的一致性，再现性是在不同条件下（不同超声仪和/或不同换能器）用相同方法获得的测量结果之间的一致性。在四个月的时间里，校准后的幻影由两名超声波技师使用两个换能器在每个阶段进行多次扫描。幻影扫描是临床QUS肝脏研究的一部分，研究对象包括肥胖和肝脏疾病严重程度的人类。在未对扫描仪进行调整之前，对每个参与者的扫描仪进行调整，以获得最高质量的肝脏b型图像。采用两种随机效应模型，采用未加权平方和方差分析方法对R&R进行分析和估计。重复性和再现性引起的测量方差很小（AC: 2.4-3.2×10−4 [dB/cm-MHz]2; 10log10BSC: 0.23-0.27 dB2）。再现性方差显著低于重复性方差。总R&R不受幻影特性的影响，在很大范围内代表了在体内肝脏中发现的那些特性。
The purpose of this study is to evaluate the repeatability and reproducibility (R&R) of quantitative ultrasound (QUS) estimates, specifically attenuation coefficient (AC) and backscattering coefficient (BSC), using the same Siemens 3000 clinical ultrasound scanner. Additionally, the purpose of this work is to detail the measurement and analysis methodology. Repeatability is closeness of agreement between measures obtained with the same method under same conditions (same sonographer and same transducer) and reproducibility is closeness of agreement between measures obtained with the same method under different conditions (different sonographers and/or different transducers). Calibrated phantoms were scanned by two sonographers using two transducers in each session for multiple sessions over a period of four months. The phantom scans occurred as part of a clinical QUS liver study in human research participants spanning a spectrum of obesity and liver disease severity. The scanner was adjusted in each participant to obtain the highest quality liver B-mode images prior to acquiring data from the phantoms for which no scanner adjustments were made. The R&R were analyzed and estimated using the unweighted sums of squares ANOVA approach by applying two random effect models. The measurement variance caused by repeatability and reproducibility is small (AC: 2.4–3.2×10−4 [dB/cm-MHz]2; 10log10BSC: 0.23–0.27 dB2). The reproducibility variance is statistically significantly lower than the repeatability variance. The total R&R was not influenced by phantom properties over a wide range representing those found in liver in vivo.