Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms
Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms
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DOI：
10.1016/j.jaip.2018.11.014
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发表时间：
2019-04-01
影响因子：
9.4
通讯作者：
Nishimura, Masaharu
中科院分区：
文献类型：
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作者：
Goudarzi, Houman;Konno, Satoshi;Nishimura, Masaharu
背景：以前的研究表明人体测量指标与哮喘症状不佳有关，尤其是在女性中。然而，内脏肥胖对哮喘症状的潜在影响还没有被调查以及目的：在这项研究中，我们已经评估了内脏肥胖是否与成人哮喘症状不佳的人体测量措施和性别。如果这种关系提出，我们调查是否可以解释的影响肺功能和/或肥胖相关的comorbidity.METHODS：我们分析了来自日本的206例哮喘患者的数据。除人体测量（体重指数和腰围）外，还通过计算机断层扫描评估腹部内脏和皮下脂肪。生活质量进行了评估，使用日本版的哮喘生活质量Questionnaire.RESULTS：所有肥胖指数与女性哮喘生活质量下降呈负相关。然而，只有内脏脂肪面积与男性哮喘生活质量问卷呈统计学负相关。只有腹部内脏脂肪与较高的胃食管反流病和抑郁评分相关。尽管所有的肥胖指数都与功能性残气量呈负相关，但只有内脏脂肪面积与FEV1%预测值呈显著负相关，与其他肥胖指数无关。不考虑性别，腹部内脏脂肪与哮喘生活质量降低相关，与其他肥胖指数无关，这可能是由于腹部内脏脂肪对减少FEV1%预测值的影响以及胃食管反流病和抑郁症的高风险。因此，内脏肥胖可能比任何其他肥胖指数对哮喘症状有更大的临床影响。(C)2018由Elsevier Inc.出版美国过敏、哮喘和免疫学会（American Academy of Allergy，Asthma & Immunology）
BACKGROUND: Previous studies have shown the association of anthropometric measures with poor asthma symptoms, especially among women. However, the potential influence of visceral adiposity on asthma symptoms has not been investigated well.OBJECTIVE: In this study, we have evaluated whether visceral adiposity is related to poor adult asthma symptoms independent of anthropometric measures and sex. If this relationship presented, we investigated whether it is explained by influence on pulmonary functions and/or obesity-related comorbidities.METHODS: We analyzed data from 206 subjects with asthma from Japan. In addition to anthropometric measures (body mass index and waist circumference), abdominal visceral and subcutaneous fat were assessed by computed tomography scan. Quality of life was assessed using the Japanese version of the Asthma Quality of Life Questionnaire.RESULTS: All obesity indices had inverse association with reduced asthma quality of life among females. However, only the visceral fat area showed a statistical inverse association with Asthma Quality of Life Questionnaire in males. Only abdominal visceral fat was associated with higher gastroesophageal reflux disease and depression scores. Although all obesity indices showed inverse association with functional residual capacity, only visceral fat area had a significant inverse association with FEV1 % predicted, independent of other obesity indices.CONCLUSIONS: Regardless of sex, abdominal visceral fat was associated with reduced asthma quality of life independent of other obesity indices, and this may be explained by the impact of abdominal visceral fat on reduced FEV1 % predicted and higher risk for gastroesophageal reflux disease and depression. Therefore, visceral adiposity may have more clinical influence than any other obesity indices on asthma symptoms. (C) 2018 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology