Electro-organic Synthesis as a Sustainable Alternative for Dehydrogenative Cross-Coupling of Phenols and Naphthols
Electro-organic Synthesis as a Sustainable Alternative for Dehydrogenative Cross-Coupling of Phenols and Naphthols
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DOI：
10.1055/s-0036-1588610
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发表时间：
2017-01-01
影响因子：
2.6
通讯作者：
Waldvogel, Siegfried R.
中科院分区：
文献类型：
--
作者：
Riehl, Barbara;Dyballa, Katrin M.;Waldvogel, Siegfried R.
酚类和萘酚类化合物的交叉偶联反应可以通过几种氧化方法实现。然而，关键是使用氟化醇，如1，1，1，3，3，3-六氟异丙醇。电的直接应用代表了一种替代的合成方法，其上级于其他氧化剂（例如，过氧化物）。该方法是可持续的，本质上是安全的，并且易于扩展。
The dehydrogenative cross-coupling of phenols and naphthols can be achieved by several oxidative methods. However, the key is the use of fluorinated alcohols such as 1,1,1,3,3,3-hexafluoroisopropanol. The direct application of electricity represents an alternative synthetic approach, which is superior to other oxidizers (e.g., peroxides). The method is sustainable, inherently safe, and easily scalable.