MEDULLARY BUT NOT CORTICAL THYMIC EPITHELIAL-CELLS PRESENT SOLUBLE-ANTIGENS TO HELPER T-CELLS
MEDULLARY BUT NOT CORTICAL THYMIC EPITHELIAL-CELLS PRESENT SOLUBLE-ANTIGENS TO HELPER T-CELLS
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DOI：
10.1084/jem.175.6.1601
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发表时间：
1992-06-01
影响因子：
15.3
通讯作者：
HIROKAWA, K
中科院分区：
文献类型：
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作者：
MIZUOCHI, T;KASAI, M;HIROKAWA, K
从新生C57 BL/6小鼠建立胸腺上皮细胞系（TEC）。它们被分为两种类型（髓质和皮质TEC），通过使用单克隆抗体（Th-3），识别胸腺皮质上皮细胞的网状结构。通过使用卵清蛋白特异性、I-A（B）限制性辅助T细胞系来测定每个TEC的抗原呈递活性。结果表明，髓质而不是皮质TEC作为抗原提呈细胞。这是皮质TEC和髓质TEC之间功能差异的第一个证据。
Thymic epithelial cell lines (TECs) were established from newborn C57BL/6 mice. They were classified into two types (medullary and cortical TECs) by using the monoclonal antibody (Th-3) that recognizes the meshwork structure of thymic cortical epithelial cells. Antigen-presenting activity of each TEC was determined by using ovalbumin-specific, I-A(b)-restricted helper T cell lines. It was demonstrated that the medullary but not the cortical TECs functioned as antigen-presenting cells. This is the first evidence for the functional difference between the cortical and the medullary TEC.