Cardiac Delayed Rectifier Potassium Channels in Health and Disease.
Cardiac Delayed Rectifier Potassium Channels in Health and Disease.
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DOI：
10.1016/j.ccep.2016.01.004
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发表时间：
2016-06
影响因子：
--
通讯作者：
Kass RS
中科院分区：
文献类型：
--
作者：
Chen L;Sampson KJ;Kass RS
心脏延迟整流钾通道在动作电位的平台期传导外向钾电流，在心脏复极过程中起关键作用。这些包括IKs、IKr和心房特异性IKur通道。在本章中，我们将回顾这些通道的分子身份和生物物理特性。编码延迟整流子的基因突变导致功能丧失或获得表型，破坏正常心脏复极并导致各种心律紊乱，包括先天性长QT综合征、短QT综合征和家族性房颤。我们还将讨论利用延迟整流通道作为治疗靶点治疗心律失常的可能性和前景。
Cardiac delayed rectifier potassium channels conduct outward potassium currents during the plateau phase of action potentials and play pivotal roles in cardiac repolarization. These include IKs, IKr and the atrial specific IKur channels. In this chapter, we will review the molecular identities and biophysical properties of these channels. Mutations in the genes encoding delayed rectifiers lead to loss- or gain-of-function phenotypes, disrupt normal cardiac repolarization and result in various cardiac rhythm disorders, including congenital Long QT Syndrome, Short QT Syndrome and familial atrial fibrillation. We will also discuss the possibility and prospect of using delayed rectifier channels as therapeutic targets to manage cardiac arrhythmia.