Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study
Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study
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DOI：
10.1002/ajmg.b.30871
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发表时间：
2008-12-05
影响因子：
2.8
通讯作者：
Gill, Michael
中科院分区：
文献类型：
--
作者：
Anney, Richard J. L.;Lasky-Su, Jessica;Gill, Michael
注意力缺陷/多动障碍（ADHD）的典型特征是注意力不集中、过度运动、冲动和注意力分散。ADHD患者在家庭和同伴关系、学习功能方面有显著损害，并且与广泛的精神障碍包括对立违抗性障碍（ODD）、行为障碍（CD）、焦虑症、抑郁症、物质滥用和广泛性发育障碍（PDD）表现出高共病率。家族研究表明，ADHD + CD代表了ADRD障碍的一种特定亚型，其家族危险因素仅与ADHD单独的家族危险因素部分重叠。我们对GAIN-ADHD样本进行了无假设分析，以确定在欧洲ADHD个体队列中发展行为问题的重要标志物和基因。使用基于家庭的关联测试（FBAT）包，我们检查了1，043，963个antosomal标记的行为问题的三个措施。这项研究是一系列探索性分析的一部分，以确定可能对ADHD和ADHD相关特征（如行为问题）重要的候选基因。我们没有发现任何测试标记和三个行为问题特征的全基因组统计学显著性（P < 5 x 10（7））。54个标记物达到强GWA信号（P < 10（-5））。我们讨论这些研究结果的背景下，假定的候选基因和这些研究结果的影响，在理解ADHD + CD的病因。我们的目的是实现洞察的遗传病因学性状使用无假设的研究设计，并能够确定一些生物学上有趣的标志物和基因的后续研究。(c)2008威利利斯公司
Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADRD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 antosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that maybe important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 x 10(7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P < 10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies. (c) 2008 Wiley-Liss, Inc.