GENETIC-LINKAGE AND COMPLEX DISEASES, WITH SPECIAL REFERENCE TO PSYCHIATRIC-DISORDERS
GENETIC-LINKAGE AND COMPLEX DISEASES, WITH SPECIAL REFERENCE TO PSYCHIATRIC-DISORDERS
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DOI：
10.1002/gepi.1370070103
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发表时间：
1990-01-01
影响因子：
2.1
通讯作者：
RISCH, N
中科院分区：
文献类型：
--
作者：
RISCH, N
最近对精神障碍，特别是精神分裂症、躁郁症和阿尔茨海默病的关联发现，提出了一些关于这些疾病的遗传病因的重要概念性问题，以及在研究复杂疾病时对关联结果的适当解释。对遗传方式、遗传异质性和表型变异进行了展望。
Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic‐depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.