Highly conserved protein kinases involved in the regulation of carbon and amino acid metabolism
Highly conserved protein kinases involved in the regulation of carbon and amino acid metabolism
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DOI：
10.1093/jxb/erh019
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发表时间：
2004-01-01
影响因子：
6.9
通讯作者：
Paul, MJ
中科院分区：
文献类型：
--
作者：
Halford, NG;Hey, S;Paul, MJ
十多年来，控制基本细胞过程的古老信号通路在真核生物中高度保守，这一点已经很明显。本文综述了两种植物蛋白激酶--蔗糖非发酵1(SNF1)相关蛋白激酶(SnRK1)和一般控制非解压2(GCN2)相关蛋白激酶。这些蛋白激酶与它们的真菌和动物同源物显示出非凡的保守性，因为它们偏离了它们的时间跨度。然而，仔细研究它们运行的信号通路，也会发现它们在激活和功能上的有趣差异。
It has been clear for over a decade and a half that ancient signalling pathways controlling fundamental cellular processes are highly conserved throughout the eukaryotes. Two plant protein kinases, sucrose non-fermenting 1 (SNF1)-related protein kinase (SnRK1) and general control non-derepressible 2 (GCN2)-related protein kinase are reviewed here. These protein kinases show an extraordinary level of conservation with their fungal and animal homologues given the span of time since they diverged from them. However, close examination of the signalling pathways in which they operate also reveals intriguing differences in activation and function.