Trends in the evolution of the proenkephalin and prodynorphin genes in gnathostomes
Trends in the evolution of the proenkephalin and prodynorphin genes in gnathostomes
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DOI：
10.1196/annals.1327.003
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Dores, RM
中科院分区：
文献类型：
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作者：
Khalap, A;Bagrosky, B;Dores, RM
阿片样物质/阿片样蛋白基因家族为分析基因组复制事件的结果提供了一个模型系统。最近的研究前脑啡肽基因提供了额外的证据，该基因的组织计划已被保存在整个广泛的辐射的有颌脊椎动物。然而，对斑马鱼（Danio rerio）脑啡肽原氨基酸序列的分析表明，这种阿片类前体的新形式可能正在硬骨鱼中进化。肌翅类强啡肽原序列的分析显示，在强啡肽原中有一个脑啡肽原的标记。目前对阿片类/β-胡萝卜素基因家族的研究指出，形成这个家族的复制事件发生在颌口动物的辐射之前。
The opioid/orphanin gene family provides a model system for analyzing the outcomes of genome duplication events. Recent studies on the proenkephalin gene provide additional evidence that the organizational plan for this gene has been conserved throughout the extensive radiation of the gnathostome vertebrates. However, an analysis of the amino acid sequence of proenkephalin from the zebrafish, Danio rerio, suggests that novel forms of this opioid precursor may be evolving in teleosts. Analyses of sarcopterygian prodynorphin sequences revealed a proenkephalin signature in prodynorphin. Current studies on the opioid/orphanin gene family point to the duplication events that shaped this family occurring prior to the radiation of the gnathostomes.