Effect of anabolic steroids on overloaded and overloaded suspended skeletal muscle.
Effect of anabolic steroids on overloaded and overloaded suspended skeletal muscle.
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合成代谢类固醇对超负荷和超负荷悬浮骨骼肌的影响。
DOI：
10.1152/jappl.1987.63.5.2128
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Baldwin,KM
中科院分区：
文献类型：
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作者：
Tsika,RW;Herrick,RE;Baldwin,KM
本研究的目的是确定合成代谢类固醇是否与功能过载协同作用，增加正常过载和悬浮过载啮齿动物跖肌的肌肉重量和亚细胞蛋白质含量。将雌性大鼠随机分为6组（7只/组），每组6只，分别为：1）正常对照组（NC）、2）超负荷组（OV）、3）超负荷类固醇组（OV-S）、4）正常悬吊组（N-SUS）、5）超负荷悬吊组（OV-SUS）和6）超负荷悬吊类固醇组（OV-SUS-S）。接受合成代谢类固醇的大鼠每天施用0.3mg癸酸诺龙（Deca-Durabolin）。相对于对照值，超负荷诱导1）OV-SUS组肌肉重量的节省以及更大的绝对和标准化OV组的肌肉重量（mg肌肉/g体重）（P <0.05），2）蛋白质含量较高（mg/肌肉，P <0.05）; 3）OV组和OV-SUS组慢肌球蛋白的相对表达均增加（P <0.05）。虽然超负荷动物（OV-S）的合成代谢类固醇治疗没有进一步改变OV组分析的任何参数的响应模式，但与对照值相比，它确实诱导了OV-SUS-S组更大的绝对和标准化肌肉重量（P <0.05）以及更大的蛋白质含量（mg/肌肉，P <0.05）。然而，合成代谢类固醇治疗并没有改变超负荷（OV-S vs. OV）或超负荷暂停（OV-SUS-S vs. OV-SUS）组中观察到的异肌球蛋白表达模式。（250字处删节）
The purpose of this study was to ascertain whether anabolic steroids act synergistically with functional overload in terms of increasing muscle weight and subcellular protein content of normal overloaded and suspended overloaded rodent plantaris muscle. Female rats were randomly assigned to six groups (7 rats/group) for 6 wk: 1) normal control (NC), 2) overload (OV), 3) overload steroid (OV-S), 4) normal suspended (N-SUS), 5) overload suspended (OV-SUS), and 6) overload suspended steroid (OV-SUS-S). Rats receiving anabolic steroid were administered 0.3 mg nandrolone decanoate (Deca-Durabolin) per day. Relative to control values, overload induced 1) sparing of muscle weight of the OV-SUS group as well as larger absolute and normalized (mg muscle/g body wt) muscle weight of the OV group (P less than 0.05), 2) greater protein content (mg/muscle, P less than 0.05), and 3) an increased relative expression of slow myosin in both the OV and OV-SUS groups (P less than 0.05). Although anabolic steroid treatment of overload animals (OV-S) did not alter further the pattern of response of any parameter analyzed for the OV group, it did induce larger absolute and normalized muscle weight (P less than 0.05) as well as a greater protein content (mg/muscle, P less than 0.05) of the OV-SUS-S group compared with control values. However, anabolic steroid treatment did not alter the pattern of isomyosin expression observed in the overload (OV-S vs. OV) or overload suspended (OV-SUS-S vs. OV-SUS) groups.(ABSTRACT TRUNCATED AT 250 WORDS)