Evaluation of Risk Factors Associated with First Episode Febrile Seizure
Evaluation of Risk Factors Associated with First Episode Febrile Seizure
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DOI：
10.7860/jcdr/2016/18635.7853
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发表时间：
2016-05-01
影响因子：
0.2
通讯作者：
Singh, Amitabh
中科院分区：
文献类型：
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作者：
Sharawat, Indar Kumar;Singh, Jitender;Singh, Amitabh
简介：热性惊厥 (FS) 是 6 个月至 5 岁儿童中最常见的癫痫发作类型。我们研究的目的是确定与首次热性惊厥发作相关的危险因素，这将有助于更好地管理和预防有 FS 发作风险的儿童。目的：评估与印度儿童首次热性惊厥发作相关的危险因素。材料和方法：这是一项以医院为基础的病例对照研究。本研究的目的是确定与儿童首次 FS 发作相关的危险因素。根据各种危险因素，将七十 (70) 名 6 个月至 5 岁之间首次发作 FS 的儿童与 70 名发烧但无癫痫发作的儿童进行比较。结果：病例的平均年龄为 24.90 +/- 16.11 个月，对照组的平均年龄为 26.34 +/- 16.93 个月。男性：女性比例为2：1。一级亲属有阳性家族史的比例为31.4%，二级亲属有阳性家族史的比例为11.4%。平均最高温度为 102.06 +/- 1.1 华氏度，URI（上呼吸道感染）是发烧的最常见原因。病例组的产前并发症明显较高。患者的 RBC（红细胞）指数较低，例如平均血红蛋白、MCV（平均红细胞体积）、MCH（平均红细胞血红蛋白浓度）和较高的 RDW（红细胞分布宽度）值。病例的血清钠、血清钙和随机血糖值均显着低于对照组（p<0.05）。结论：我们的研究表明，男性、热性惊厥家族史、最高体温、发热的根本原因、产前并发症、低血钙、低钠、低血糖和小细胞低色素性贫血是与首次热性惊厥发生相关的危险因素，因此，消除这些危险因素的预防措施可能会导致热性惊厥发生率的降低。 FS。
Introduction: Febrile seizure (FS) is the single most common type of seizure seen in children between 6 months to 5 years of age. The purpose of our study was to identify the risk factors associated with the first episode of febrile seizures, which would help in the better management and preventive measures in children at risk for FS episodes.Aim: To evaluate the risk factors associated with the first episode of febrile seizures in Indian children.Materials and Methods: This was a hospital based, case control study. The purpose of this study was to identify the risk factors associated with the first FS episode in children. Seventy (70) children between age 6 months to 5 years with their first episode of FS were compared with 70 children with fever but without seizures based on various risk factors.Results: The mean age was 24.90 +/- 16.11 months in cases and 26.34 +/- 16.93 months in controls. Male: female ratio was 2: 1. A positive family history was found in 31.4% of first degree and 11.4% in second degree relatives. Mean maximum temperature was 102.06 +/- 1.1 degrees F and URI (upper respiratory infection) was most common cause of fever. Antenatal complication was significantly higher in the case group. RBC (Red Blood Cells) indices like lower mean haemoglobin, MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Haemoglobin concentration) and higher RDW (Red Cell Distribution Width) values were seen in patients. Serum sodium, Serum calcium and random blood sugar values of the cases were significantly lower than those of controls (p< 0.05).Conclusion: Our study shows that male gender, family history of febrile seizures, peak body temperature, underlying cause of fever, antenatal complications, low serum calcium, sodium, blood sugar and microcytic hypochromic anaemia are the risk factors associated with the occurrence of first episode of febrile seizure and, thus, preventive measures in removing these risk factors could lead to a decrease in incidence of FS.