Sinking while you swim: A dual role for CCR7 in leukocyte migration.
Sinking while you swim: A dual role for CCR7 in leukocyte migration.
复制标题
游泳时下沉：CCR7 在白细胞迁移中的双重作用。
DOI：
10.1126/sciimmunol.adj3102
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发表时间：
2023
影响因子：
24.8
通讯作者：
Donnelly H
中科院分区：
文献类型：
--
作者：
Donnelly H
CCR7 受体允许树突状细胞感知趋化因子 CCL19。它还通过内吞作用从环境中耗尽 CCL19，从而产生局部梯度，可以准确、稳健地引导细胞穿过组织，甚至是长距离（参见 Alankoet 等人的相关研究文章）。
The CCR7 receptor allows dendritic cells to sense the chemokine CCL19. It also depletes CCL19 from the environment by endocytosis, leading to local gradients that can steer cells accurately and robustly through tissues, even over long distances (see related Research Article by Alankoet al.).