Unique Features of Pancreatic-Resident Regulatory T Cells in Autoimmune Type 1 Diabetes.
Unique Features of Pancreatic-Resident Regulatory T Cells in Autoimmune Type 1 Diabetes.
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胰腺驻留调节性 T 细胞在自身免疫 1 型糖尿病中的独特特征
DOI：
10.3389/fimmu.2017.01235
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发表时间：
2017
影响因子：
7.3
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Lu J;Zhang C;Li L;Xue W;Zhang C;Zhang X
调节性T细胞（Tcells，Tcells）生物学的最新进展强调了理解组织驻留Tcells对组织特异性环境的响应的重要性。现在，新出现的证据表明，胰腺居民叉头盒P3+ TdR对抑制自身免疫性1型糖尿病（T1D）过度旺盛的免疫反应具有明显的作用。因此，人们越来越感兴趣的是阐明胰腺驻留TdR在局部环境中发挥作用和进化的作用。在这篇综述中，我们讨论了驻留在胰腺组织和胰腺淋巴结中的TlD的表型和功能，重点是TlD中控制疾病进展的TlD的独特亚群。具体来说，我们讨论了已知的和可能的调制器，影响生存，迁移和维持胰腺TGFAP。
Recent progress in regulatory T cells (Tregs) biology emphasizes the importance of understanding tissue-resident Tregs in response to tissue-specific environment. Now, emerging evidence suggests that pancreatic-resident forkhead box P3+ Tregs have distinguishable effects on the suppression of over-exuberant immune responses in autoimmune type 1 diabetes (T1D). Thus, there is growing interest in elucidating the role of pancreatic-resident Tregs that function and evolve in the local environment. In this review, we discuss the phenotype and function of Tregs residing in pancreatic tissues and pancreatic lymph nodes, with emphasis on the unique subpopulations of Tregs that control the disease progression in the context of T1D. Specifically, we discuss known and possible modulators that influence the survival, migration, and maintenance of pancreatic Tregs.