Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats.
Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats.
复制标题
吗啡和纳洛酮对青春期前雄性和雌性大鼠血清黄体生成素和催乳素水平的影响。
作者：
T. Ieiri;H. T. Chen;J. Meites
观察了吗啡(M)和纳洛酮(N)对青春期前雄性和雌性大鼠血清黄体生成素(LH)和催乳素(PRL)水平的影响。雌性大鼠在10、15、20、25和30日龄时血清黄体生成素水平升高，而雄性青春期前大鼠仅在30日龄时血清黄体生成素水平升高。M只在15日龄时显着降低雌雄个体的血清LH值。除25日龄雄性大鼠外，M使所有年龄组的雌雄幼鼠血清PRL水平均升高，而N只降低25日龄雄性大鼠的血清PRL水平。这些结果表明，未成熟大鼠对M或N的反应与已报道的成熟大鼠的不同，提示内源性阿片肽可能对未成熟大鼠的黄体生成素和催乳素的分泌有调节作用。
The effects of morphine (M) and naloxone (N) on serum levels of luteinizing hormone (LH) and prolactin (PRL) in prepubertal male and female rats were investigated. N raised serum LH concentrations in female rats at 10, 15, 20, 25 and 30 days of age, but increased serum LH levels in male prepubertal rats only at 30 days of age. M significantly depressed serum LH values in both sexes only at 15 days of age. M increased serum PRL levels in immature rats of both sexes in all age groups, except in 25-day-old males, whereas N decreased serum PRL only in 25-day-old male rats. These data show that there are differences in the pituitary LH and PRL responses to M or N of immature as compared to the responses previously reported in mature rats, and suggest that the endogenous opioid peptides may have a role in regulating LH and PRL secretion in immature rats.