Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.
Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.
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性类固醇激素对学习和记忆至关重要：男性和雌性啮齿动物中海马功能的雌激素调节。
DOI：
10.1101/lm.037267.114
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Fortress AM
中科院分区：
文献类型：
--
作者：
Frick KM;Kim J;Tuscher JJ;Fortress AM
大量证据表明，性类固醇激素，如强效雌激素17β-雌二醇（E2），影响雄性和雌性啮齿动物的海马形态、可塑性和记忆。然而，研究男性受试者的研究人员很少考虑这些激素对学习和记忆的影响。本文综述了E2对海马棘发生、神经发生、生理和记忆的影响，特别关注E2对雄性啮齿动物的影响。雌激素受体，细胞信号传导途径，和E2增强雌性啮齿动物记忆所必需的表观遗传过程也进行了详细讨论。最后，与女性啮齿动物工作的实际考虑，为那些研究人员考虑添加女性到他们的实验设计。
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes the effects of E2 on hippocampal spinogenesis, neurogenesis, physiology, and memory, with particular attention paid to the effects of E2 in male rodents. The estrogen receptors, cell-signaling pathways, and epigenetic processes necessary for E2 to enhance memory in female rodents are also discussed in detail. Finally, practical considerations for working with female rodents are described for those investigators thinking of adding females to their experimental designs.