Novel and unusual nucleosides as drugs.
Novel and unusual nucleosides as drugs.
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作为药物的新颖和不寻常的核苷。
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
V. Kolb
中科院分区：
文献类型：
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作者：
V. Kolb
核苷最重要的功能是它们是核酸的组成部分。后者代表了生物体的蓝图，决定了生物化学过程和繁殖能力[1,2]。核苷由杂环氮基组成，通常通过β - n -糖苷键与戊糖相连。核苷基是嘌呤（通常是腺嘌呤和鸟嘌呤）和嘧啶（通常是胞嘧啶、胸腺嘧啶和尿嘧啶）的衍生物。戊糖部分在核糖核苷中是核糖，在脱氧核糖核苷中是脱氧核糖。核苷酸是戊糖磷酸化的核苷衍生物，通常在5 ' -羟基上磷酸化[1,2]。图1显示了常见核苷的结构，核苷是核酸的组成部分，因此是遗传系统的基础。
The most important function of nucleosides is that they are components of the nucleic acids. The latter represent the blue print of organisms and determine the biochemical processes and the ability to reproduce [1,2]. Nucleosides are composed of a heterocyclic nitrogenous base linked typically to a pentose via a beta-N-glycosidic bond. The nucleoside bases are derivatives of purine, commonly adenine and guanine, and pyrimidine, commonly cytosine, thymine, and uracil. The pentose moiety is ribose in ribonucleosides, and deoxyribose in deoxyribonucleosides. Nucleotides are nucleoside derivatives in which pentose is phosphorylated, usually at the 5′-hydroxyl group [1,2]. Figure 1 shows structures of common nucleosides which are the components of nucleic acids and thus are the basis of the genetic system.
通过掺入非极性、非氢键核苷等排体形成稳定的 DNA 环。
DOI：
10.1002/anie.199607431
发表时间：
1996
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
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作者：
Ren,Xiao-Feng;Schweitzer,BarbaraA;Sheils,CharlesJ;Kool,EricT
通讯作者：
Kool,EricT
戊糖部分的修饰和构象变化对核苷配体与弓形虫尿苷磷酸化酶结合的影响。
影响因子：
5.8
作者：
elKouni,MH;Naguib,FN;Panzica,RP;Otter,BA;Chu,SH;Gosselin,G;Chu,CK;Schinazi,RF;Shealy,YF;Goudgaon,N;Ozerov,AA;Ueda,T;Iltzsch,MH
通讯作者：
Iltzsch,MH